Fever and Cutaneous Nodules

  • Sowmya ShashidharaEmail author
  • H. Koushik
  • Sangita Trivedi


  • Parvovirus is a single-stranded DNA virus which causes aplastic crises in children with sickle cell disease or other forms of anemia

  • Younger children are more susceptible to parvovirus infection

  • Although sickle cell disease is a state of chronic immunosuppression, cell-mediated immunity remains relatively intact

  • Penicillin prophylaxis is a part of routine care to prevent infection with encapsulated organisms up to 5 years of age and indefinitely in sickle cell patients who have suffered a previous pneumococcal disease


Aplastic crisis Parvovirus Sickle cell anemia 


  1. 1.
    Heegaard ED, Brown KE. Human Parvovirus B19. Clin Microbiol Rev. 2002;15(3):485–505.CrossRefGoogle Scholar
  2. 2.
    Rao SP, Miller ST, Cohen BJ. Transient aplastic crisis in patients with sickle cell disease. B19 parvovirus studies during a 7-year period. Am J Dis Child. 1992;146(11):1328–30.CrossRefGoogle Scholar
  3. 3.
    Booth C, Inusa B, Obaro SK. Infection in sickle cell disease: a review. Int J Infect Dis. 2010;1:e2–e12.CrossRefGoogle Scholar
  4. 4.
    Onwubalili JK. Sickle cell disease and infection. J Infect. 1983;7(1):2–20.CrossRefGoogle Scholar
  5. 5.
    DeBaun MR. Hemoglobinopathies. In: Kliegman RM, St Geme JWS, Schor NF, editors. Nelson’s textbook of pediatrics, vol. 2. 20th ed. Philadelphia, PA: Elsevier; 2016. p. 2336–53.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sowmya Shashidhara
    • 1
    • 2
    Email author
  • H. Koushik
    • 1
  • Sangita Trivedi
    • 3
  1. 1.Department of PediatricsKasturba Medical College, Manipal UniversityManipalIndia
  2. 2.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)Universal Scientific Education and Research Network (USERN)ManipalIndia
  3. 3.Department of PediatricsGovernment Medical College, Surat, Veer Narmad South Gujarat UniversitySuratIndia

Personalised recommendations