Puffy Face and Abdominal Distension

  • Sowmya ShashidharaEmail author
  • H. Koushik
  • Sangita Trivedi


  • All live vaccines are contraindicated in children who are immunosuppressed secondary to disease or immunosuppressive therapy

  • Calcineurin inhibitors are commonly used immunosuppressive agents and act via cyclophilin and inhibit IL-2 production

  • The thiopurine S-methyltransferase pharmacogenetic testing is recommended before using thiopurine drugs for immunosuppression

  • Tacrolimus therapy is associated with subsequent cancer risk

  • Febrile neutropenia in low risk patients is treated with empirical antibiotics

  • Colony-stimulating factors are used to treat prolonged neutropenia secondary to immunosuppressive therapy


Calcineurin inhibitors Thiopurine S-methyltransferase Cyclosporine A Live vaccines 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sowmya Shashidhara
    • 1
    • 2
    Email author
  • H. Koushik
    • 1
  • Sangita Trivedi
    • 3
  1. 1.Department of PediatricsKasturba Medical College, Manipal UniversityManipalIndia
  2. 2.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)Universal Scientific Education and Research Network (USERN)ManipalIndia
  3. 3.Department of PediatricsGovernment Medical College, Surat, Veer Narmad South Gujarat UniversitySuratIndia

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