Advertisement

Puffy Face and Abdominal Distension

  • Sowmya ShashidharaEmail author
  • H. Koushik
  • Sangita Trivedi
Chapter

Abstract

  • All live vaccines are contraindicated in children who are immunosuppressed secondary to disease or immunosuppressive therapy

  • Calcineurin inhibitors are commonly used immunosuppressive agents and act via cyclophilin and inhibit IL-2 production

  • The thiopurine S-methyltransferase pharmacogenetic testing is recommended before using thiopurine drugs for immunosuppression

  • Tacrolimus therapy is associated with subsequent cancer risk

  • Febrile neutropenia in low risk patients is treated with empirical antibiotics

  • Colony-stimulating factors are used to treat prolonged neutropenia secondary to immunosuppressive therapy

Keywords

Calcineurin inhibitors Thiopurine S-methyltransferase Cyclosporine A Live vaccines 

References

  1. 1.
    (ACIP) ACoIP. General best practice guidelines for immunization: best practices guidance of the Advisory Committee on Immunization Practices (ACIP). Atlanta, GA: Advisory Committee on Immunization Practices; 2017.Google Scholar
  2. 2.
    Li S, Yang H, Guo P, Ao X, Wan J, Li Q, Tan L. Efficacy and safety of immunosuppressive medications for steroid-resistant nephrotic syndrome in children: a systematic review and network meta-analysis. Oncotarget. 2017;8(42):73050–62.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Azzi JR, Sayegh MH, Mallat SG. Calcineurin inhibitors: 40 years later, can’t live without. J Immunol. 2013;191(12):5785–91.CrossRefGoogle Scholar
  4. 4.
    Asadov C, Aliyeva G, Mustafayeva K. Thiopurine S-methyltransferase as a pharmacogenetic biomarker: significance of testing and review of major methods. Cardiovasc Hematol Agents Med Chem. 2017;15:23–30.CrossRefGoogle Scholar
  5. 5.
    Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev. 1999;12(2):310–50.CrossRefGoogle Scholar
  6. 6.
    Robinson PD, Lehrnbecher T, Phillips R, Dupuis LL, Sung L. Strategies for empiric management of pediatric fever and neutropenia in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review of randomized trials. J Clin Oncol. 2016;34(17):2054–60.CrossRefGoogle Scholar
  7. 7.
    Mehta HM, Malandra M, Corey SJ. G-CSF and GM-CSF in neutropenia. J Immunol. 2015;195(4):1341–9.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sowmya Shashidhara
    • 1
    • 2
    Email author
  • H. Koushik
    • 1
  • Sangita Trivedi
    • 3
  1. 1.Department of PediatricsKasturba Medical College, Manipal UniversityManipalIndia
  2. 2.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)Universal Scientific Education and Research Network (USERN)ManipalIndia
  3. 3.Department of PediatricsGovernment Medical College, Surat, Veer Narmad South Gujarat UniversitySuratIndia

Personalised recommendations