A 47-year-old woman with progressive numbness and weakness in the limbs

  • Lingchao Meng
  • Yun Yuan
  • Shan Chen


We present a case of toxic polyneuropathy induced by the exposure to leather cements in shoe industries. A nerve biopsy showed the presence of “giant axons” similar to hereditary giant axonal neuropathy (GAN) caused by recessive mutations in the GAN gene encoding gigaxonin. Similar case reports in the literature suggest that it is due to chronic intoxication of n-hexane found in the cements used in the shoe manufacturing process. The neuropathy symptoms in our patient significantly improved after discontinuing the exposure.


N-hexane Giant axonal neuropathy Sural nerve biopsy 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Lingchao Meng
    • 1
  • Yun Yuan
    • 1
  • Shan Chen
    • 2
  1. 1.Neuromuscular Division, Department of NeurologyPeking University First HospitalBeijingChina
  2. 2.Peripheral Neuropathy CenterRutgers University, Robert Wood Johnson Medical SchoolNew BrunswickUSA

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