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Dietary Restriction, Cardiovascular Aging and Age-Related Cardiovascular Diseases: A Review of the Evidence

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Reviews on Biomarker Studies in Aging and Anti-Aging Research

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1178))

Abstract

Both morbidity and mortality due to cardiovascular diseases (CVDs) elevate with age. The elevated prevalence of cardiovascular risk factors with age and cardiovascular aging contribute to the relationship between aging and CVDs. Dietary restriction (DR) consisting of calorie restriction (CR) and alternate-day fasting (ADF) is an approved nutritional intervention and shows anti-aging impacts. Recent studies demonstrate that DR makes an active defense response in stressful states. At the core of this response are cardiovascular protective signals, which consist of the mammalian target of rapamycin (mTOR), AMP-activated kinase, sirtuins and endothelial nitric oxide synthase. These make a network with positive and negative feedback regulation. Hence, DR is a hopeful intervention for controlling cardiovascular aging and managing individuals with CVDs.

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Author information

Authors and Affiliations

  1. Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Behnaz Abiri

  2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Mohammadreza Vafa

  3. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

    Mohammadreza Vafa

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  1. Behnaz Abiri
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Correspondence to Mohammadreza Vafa .

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Editors and Affiliations

  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Abiri, B., Vafa, M. (2019). Dietary Restriction, Cardiovascular Aging and Age-Related Cardiovascular Diseases: A Review of the Evidence. In: Guest, P. (eds) Reviews on Biomarker Studies in Aging and Anti-Aging Research. Advances in Experimental Medicine and Biology(), vol 1178. Springer, Cham. https://doi.org/10.1007/978-3-030-25650-0_7

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