Current and Emerging Treatment Strategies for Primary Mediastinal B-Cell Lymphoma

  • Christin B. DeStefano
  • Kieron Dunleavy
  • Catherine LaiEmail author


Primary mediastinal B-cell lymphoma is rare, representing less than 5% of all non-Hodgkin lymphomas. Given its rarity, the only studies from which to derive optimal management are single arm, retrospective, or subgroup analyses of larger studies. Despite the paucity of high-level evidence, the historical standard frontline treatment is R-CHOP followed by consolidative mediastinal radiotherapy. Recent data suggest that increased intensity chemoimmunotherapy may obviate the need for mediastinal radiotherapy in the frontline setting and that combinations or sequences of novel immunotherapies, small molecule inhibitors, and monoclonal antibodies may improve outcomes in the relapsed or refractory setting which otherwise carries a dismal prognosis.


Primary mediastinal B-cell lymphoma Chemotherapy Radiation therapy Checkpoint inhibitors CAR-T cells Monoclonal antibodies Small molecule inhibitors 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Christin B. DeStefano
    • 1
  • Kieron Dunleavy
    • 2
  • Catherine Lai
    • 3
    Email author
  1. 1.Uniformed Services UniversityBethesdaUSA
  2. 2.George Washington University HospitalWashington, DCUSA
  3. 3.MedStar Georgetown University HospitalWashington, DCUSA

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