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Anaplastic Large Cell Lymphoma

  • Austin KimEmail author
  • Eric Jacobsen
Chapter

Abstract

Anaplastic large cell lymphoma (ALCL) is one of the most common subtypes of peripheral T-cell lymphomas (PTCLs). ALCL is an aggressive lymphoma with anaplastic lymphoma kinase-positive (ALK-positive) ALCL generally having a better prognosis and occurring in younger patients than ALK-negative ALCL. Multiagent chemotherapy, now with the addition of brentuximab vedotin, an anti-CD30 monoclonal antibody-drug conjugate, is the recommended initial therapy for ALCL with high-dose chemotherapy and autologous stem cell rescue reserved for consolidation of patients at high risk of relapse. Novel treatments targeting the universally expressed surface receptor on ALCL cells, CD30, and the ALK tyrosine kinase receptor inhibitors have provided patients with relapsed or refractory ALCL more effective treatment options.

Keywords

Anaplastic large cell lymphoma (ALCL) Anaplastic lymphoma kinase (ALK) ALK-positive ALCL ALK-negative ALCL Brentuximab vedotin (BV) CD30 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Harvard Medical School, Dana-Farber Cancer InstituteBostonUSA

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