Biocatalysis pp 309-331 | Cite as

Proteinaceous Trypsin Inhibitors from Plants in Disarming the Insect Pest

  • Farrukh Jamal
  • Sangram Singh
  • Prabhash Kumar Pandey
  • Ranjan Singh


The resurgence of resistance to inhibitors in insects has necessitated the search for newer and more effective biological means of controlling insects. Inhibitors from diverse sources are being explored for understanding their inhibitory potential. Among the alternatives, protease inhibitors represent an attractive class of biopesticides with several important features. Such protease inhibitors are environmentally friendly to work as defense molecules against plant pest and pathogen. Helicoverpa armigera is a voracious feeder blessed with the destructive potential of crop plants. These “eating machines” have robust metabolic processes and exhibit much faster growth and development. Targeting digestive enzymes and/or chitin present in the peritrophic membrane, a film like structure that separates food from the gut tissue of many insect pests is gaining emphasis in alternative pest control strategies. This article presents some recently explored proteins that exhibit enormous potential in biocontrol of insect pests.


Inhibitor proteins Gut protease Trypsin inhibitor Developmental physiology Biocontrol Insect pests 



The authors express their gratitude to Ministry of Science and Technology, Govt. of India and University Grants Commission, New Delhi for providing financial support to the department under the DST-FIST scheme for developing infrastructure to carry out work on such aspects. Prabhash K. Pandey gratefully acknowledges University Grant Commission, New Delhi for providing the financial assistance (UGC-DSKPDF No.F.4-2/2006 BSR/BL/17-18/0442). The corresponding author is thankful to the Council of Science and Technology, U.P. India for providing recurring financial support vide project CST/SERPD/D-1136.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Farrukh Jamal
    • 1
  • Sangram Singh
    • 1
  • Prabhash Kumar Pandey
    • 2
  • Ranjan Singh
    • 3
  1. 1.Department of BiochemistryDr. Rammanohar Lohia Avadh UniversityFaizabadIndia
  2. 2.Department of BiochemistryUniversity of AllahabadAllahabadIndia
  3. 3.Department of BiotechnologyCoithram College of Professional StudiesIndoreIndia

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