Biocatalysis pp 213-231 | Cite as

Clinical Significance of Enzymes in Disease and Diagnosis

  • Mohammad Fahad UllahEmail author
  • Showket H. Bhat
  • Muhammad Tariq
  • Faisel M. Abuduhier


Over the years, enzymes have emerged as critical regulators of human diseases. In addition, as biomarkers, some enzymes often present consequential cue about the disease state due to their corresponding altered pattern in tissues and serum. A vast embodiment of data from experimental research in model organisms and humans has ensured the clinical utilization of specific enzymes as an evidence-based strategy in disease prevention and diagnosis. These have been incorporated in the diagnostic premises as biomarkers, which are quantifiable laboratory measure of a disease specific biologically relevant molecule that can act as an indicator of a disease burden. This chapter provides a brief review of the current paradigm on harnessing the clinical utility of enzymes with potential impact in the diagnosis of cancer disease, myocardial disorders and gastrointestinal tract related impairments in humans.


Diagnostic enzymes Cancer Myocardial disease Hepatic disease Biomarker 



We thankfully acknowledge the authors and the publishers of the articles from where the Fig. 1 has been reproduced, and note that since a brief overview on the subject was attempted, some worthwhile studies and relevant observations may have been inadvertently missed.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mohammad Fahad Ullah
    • 1
    Email author
  • Showket H. Bhat
    • 1
  • Muhammad Tariq
    • 1
  • Faisel M. Abuduhier
    • 1
  1. 1.Faculty of Applied Medical Science, Prince Fahd Research Chair, Department of Medical Laboratory TechnologyUniversity of TabukTabukSaudi Arabia

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