Liver Diseases pp 811-827 | Cite as

Future Approaches in Liver Disorders: Regenerative Medicine

  • Mariana Jinga
  • Vasile Daniel Balaban
  • Ecaterina Bontas
  • Ion C. Tintoiu


End-stage liver disease benefits only from liver transplantation. As we shall see, the emerging field of regenerative medicine offers novel approaches to liver disease treatment based on a remarkable progress in basic biomedical research during the last 20–30 years. In this context, the major methods of regenerative medicine are cell therapy, tissue/organ engineering and bioartificial liver with promising results. At the present time, cell therapy is an important tool to evaluate liver regeneration, hepatoxicity of xenobiotics by CYP enzymes, and drug interactions. Moreover, bioartificial livers can remove the problematic lack of donor liver and allow disease modeling. Ultimately, advancements in liver genome editing might treat either hereditary monogenic liver disorders or viral hepatitis. Herein, we discuss the basic knowledge of liver regeneration and highlight the current methods of liver regenerative medicine.


Liver regeneration Cell therapy Hepatocyte-like cells Organoids Bioartificial liver Bioprinted tissues Tissue engineering Gene editing platforms 



Activating Transcription Factor 5


bioartificial liver


bone morphogenetic protein


CCAAT/enhancer binding protein (C/EBP) alpha


cytochrome P450


DNA methylation inhibitor


epidermal growth factor


embryonic stem cells


fibroblast growth factor


fibroblast growth factor


Forkhead Box A1


Forkhead Box A2


Forkhead Box A3


Granulocyte-colony stimulating factor


histone deacetylase inhibitor


hepatocyte growth factor


Hepatocyte like-cells


hepatocyte nuclear factor 1 alpha or hepatocyte nuclear factor 1 homeobox alpha


hepatocyte nuclear factor 4 alpha


hematopoietic stem cells




induced pluripotent stem cells


liver stem/progenitor cells


Model For End-Stage Liver Disease


MicroRNA 122


mesenchymal stem cells


Nonalcoholic steatohepatitis


oncostatin M


peroxisome proliferator-activated receptor α


pluripotent stem cells


transforming growth factor


tumor necrosis factor alpha


platelet-derived growth factors


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mariana Jinga
    • 1
  • Vasile Daniel Balaban
    • 1
  • Ecaterina Bontas
    • 2
  • Ion C. Tintoiu
    • 3
  1. 1.Central Military Emergency University Hospital “Dr. Carol Davila”Carol Davila University of Medicine and PharmacyBucharestRomania
  2. 2.“Prof. C.C. Iliescu” Emergency Institute for Cardiovascular DiseasesBucharestRomania
  3. 3.Faculty of Medicine, “Carol Davila” Central Military Emergency University Hospital“Titu Maiorescu” UniversityBucharestRomania

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