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Liver Diseases pp 513-521 | Cite as

Ultrasound Elastography

  • Woo Kyoung Jeong
Chapter

Abstract

Ultrasound elastography (USE) of the liver is highlighted as a non-invasive tool for replacement of liver biopsy for hepatic fibrosis staging. There are several different methods used in clinical field: transient elastography (TE), point shear wave elastography (pSWE), and two-dimensional shear wave elastography (2D-SWE). The diagnostic accuracy of pSWE and 2D-SWE is about 85% of sensitivity and 90% of specificity, comparable or superior to TE. However, there are remained issues such as penetration, measurement protocols, unit of measurement, and difficulty of comparison between machines. In future, the standard measurement protocol should be needed to expand the indication of USE.

Keywords

Elastography Fibrosis Cirrhosis Reliability Liver stiffness measurement 

References

  1. 1.
    Youk JH, Gweon HM, Son EJ. Shear-wave elastography in breast ultrasonography: the state of the art. Ultrasonography. 2017;36:300–9.PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Kwak JY, Kim EK. Ultrasound elastography for thyroid nodules: recent advances. Ultrasonography. 2014;33:75–82.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Jeong WK, Lim HK, Lee HK, Jo JM, Kim Y. Principles and clinical application of ultrasound elastography for diffuse liver disease. Ultrasonography. 2014;33:149–60.PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003;38:1449–57.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Dietrich CF, Bamber J, Berzigotti A, et al. EFSUMB guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (short version). Ultraschall Med. 2017;38:377–94.PubMedCrossRefGoogle Scholar
  6. 6.
    Barr RG, Ferraioli G, Palmeri ML, et al. Elastography assessment of liver fibrosis: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2015;276:845–61.PubMedCrossRefGoogle Scholar
  7. 7.
    Ziol M, Handra-Luca A, Kettaneh A, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005;41:48–54.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Park SH, Kim SY, Suh CH, et al. What we need to know when performing and interpreting US elastography. Clin Mol Hepatol. 2016;22:406–14.PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Friedrich-Rust M, Poynard T, Castera L. Critical comparison of elastography methods to assess chronic liver disease. Nat Rev Gastroenterol Hepatol. 2016;13:402–11.PubMedCrossRefGoogle Scholar
  10. 10.
    Sarvazyan AP, Skovoroda AR, Emelianov SY, et al. Biophysical bases of elasticity imaging. In: Jones JP, editor. Acoustical imaging, vol. 21. Boston, MA: Springer; 1995. p. 223–40.CrossRefGoogle Scholar
  11. 11.
    Jiang T, Tian G, Zhao Q, et al. Diagnostic accuracy of 2D-shear wave elastography for liver fibrosis severity: a meta-analysis. PLoS One. 2016;11:e0157219.PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Bota S, Herkner H, Sporea I, et al. Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Liver Int. 2013;33:1138–47.PubMedCrossRefGoogle Scholar
  13. 13.
    Friedrich-Rust M, Nierhoff J, Lupsor M, et al. Performance of acoustic radiation force impulse imaging for the staging of liver fibrosis: a pooled meta-analysis. J Viral Hepat. 2012;19:e212–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Chon YE, Choi EH, Song KJ, et al. Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. PLoS One. 2012;7:e44930.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Tsochatzis EA, Gurusamy KS, Ntaoula S, Cholongitas E, Davidson BR, Burroughs AK. Elastography for the diagnosis of severity of fibrosis in chronic liver disease: a meta-analysis of diagnostic accuracy. J Hepatol. 2011;54:650–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Friedrich-Rust M, Ong MF, Martens S, et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology. 2008;134:960–74.PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Oliveri F, Coco B, Ciccorossi P, et al. Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases. World J Gastroenterol. 2008;14:6154–62.PubMedPubMedCentralCrossRefGoogle Scholar
  18. 18.
    Sasso M, Beaugrand M, de Ledinghen V, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol. 2010;36:1825–35.PubMedCrossRefGoogle Scholar
  19. 19.
    Karlas T, Petroff D, Sasso M, et al. Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis. J Hepatol. 2017;66(5):1022–30.PubMedCrossRefGoogle Scholar
  20. 20.
    Kwon HJ, Kim KW, Jung JH, et al. Noninvasive quantitative estimation of hepatic steatosis by ultrasound: a comparison of the hepato-renal index and ultrasound attenuation index. Med Ultrason. 2016;18:431–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Festi D, Schiumerini R, Marzi L, et al. Review article: The diagnosis of non-alcoholic fatty liver disease—availability and accuracy of non-invasive methods. Aliment Pharmacol Ther. 2013;37:392–400.PubMedCrossRefGoogle Scholar
  22. 22.
    Sanyal AJ, Bosch J, Blei A, Arroyo V. Portal hypertension and its complications. Gastroenterology. 2008;134:1715–28.PubMedCrossRefGoogle Scholar
  23. 23.
    D’Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology. 2006;131:1611–24.PubMedCrossRefGoogle Scholar
  24. 24.
    Garcia-Tsao G, Abraldes JG, Berzigotti A, Bosch J. Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases. Hepatology. 2017;65:310–35.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Vizzutti F, Arena U, Romanelli RG, et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. 2007;45:1290–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Shi KQ, Fan YC, Pan ZZ, et al. Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease. Liver Int. 2013;33:62–71.PubMedCrossRefGoogle Scholar
  27. 27.
    Choi SY, Jeong WK, Kim Y, Kim J, Kim TY, Sohn JH. Shear-wave elastography: a noninvasive tool for monitoring changing hepatic venous pressure gradients in patients with cirrhosis. Radiology. 2014;273:917–26.PubMedCrossRefGoogle Scholar
  28. 28.
    Reiberger T, Ferlitsch A, Payer BA, et al. Non-selective beta-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis. J Gastroenterol. 2012;47:561–8.PubMedCrossRefGoogle Scholar
  29. 29.
    Berzigotti A. Non invasive evaluation of portal hypertension using ultrasound elastography. J Hepatol. 2017;67(2):399–411.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Kim SU, Seo YS, Cheong JY, et al. Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B. Aliment Pharmacol Ther. 2010;32:498–505.PubMedCrossRefPubMedCentralGoogle Scholar
  31. 31.
    Gerber L, Kasper D, Fitting D, et al. Assessment of liver fibrosis with 2-D shear wave elastography in comparison to transient elastography and acoustic radiation force impulse imaging in patients with chronic liver disease. Ultrasound Med Biol. 2015;41:2350–9.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Cassinotto C, Lapuyade B, Ait-Ali A, et al. Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography—comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease. Radiology. 2013;269:283–92.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Sporea I, Sirli R, Bota S, Popescu A, Sendroiu M, Jurchis A. Comparative study concerning the value of acoustic radiation force impulse elastography (ARFI) in comparison with transient elastography (TE) for the assessment of liver fibrosis in patients with chronic hepatitis B and C. Ultrasound Med Biol. 2012;38:1310–6.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Ferraioli G, Maiocchi L, Lissandrin R, et al. Accuracy of the ElastPQ technique for the assessment of liver fibrosis in patients with chronic hepatitis C: a “Real Life” single center study. J Gastrointestin Liver Dis. 2016;25:331–5.PubMedPubMedCentralGoogle Scholar
  35. 35.
    Bota S, Sporea I, Sirli R, Popescu A, Jurchis A. Factors which influence the accuracy of acoustic radiation force impulse (ARFI) elastography for the diagnosis of liver fibrosis in patients with chronic hepatitis C. Ultrasound Med Biol. 2013;39:407–12.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Lim S, Kim SH, Kim Y, et al. Coefficient of variance as quality criterion for evaluation of advanced hepatic fibrosis using 2D shear-wave elastography. J Ultrasound Med. 2018;37:355–62.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Ferraioli G, Tinelli C, Dal Bello B, et al. Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: a pilot study. Hepatology. 2012;56:2125–33.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Choi SH, Jeong WK, Kim Y, et al. How many times should we repeat measuring liver stiffness using shear wave elastography?: 5-repetition versus 10-repetition protocols. Ultrasonics. 2016;72:158–64.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Thiele M, Madsen BS, Procopet B, et al. Reliability criteria for liver stiffness measurements with real-time 2D shear wave elastography in different clinical scenarios of chronic liver disease. Ultraschall Med. 2017;38(6):648–54.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Procopet B, Berzigotti A, Abraldes JG, et al. Real-time shear-wave elastography: applicability, reliability and accuracy for clinically significant portal hypertension. J Hepatol. 2015;62:1068–75.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Yoon KJ, Jeong WK, Kim Y, Kim MY, Kim TY, Sohn JH. 2-Dimensional shear wave elastography: interobserver agreement and factors related to interobserver discrepancy. PLoS One. 2017;12(4):e0175747.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    Cassinotto C, de Ledinghen V. Reply to: “New imaging assisted methods for liver fibrosis quantification: is it really favorable to classical transient elastography?”. J Hepatol. 2015;63:767.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Cassinotto C, Charrie A, Mouries A, et al. Liver and spleen elastography using supersonic shear imaging for the non-invasive diagnosis of cirrhosis severity and oesophageal varices. Dig Liver Dis. 2015;47:695–701.PubMedCrossRefPubMedCentralGoogle Scholar
  44. 44.
    Madsen EL, Sathoff HJ, Zagzebski JA. Ultrasonic shear wave properties of soft tissues and tissuelike materials. J Acoust Soc Am. 1983;74:1346–55.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Palmeri M, Nightingale K, Fielding S, et al. RSNA QIBA ultrasound shear wave speed Phase II phantom study in viscoelastic media. Taipei, Taiwan: IEEE; 2015. p. 1–4.Google Scholar
  46. 46.
    Hall TJ, Milkowski A, Garra B, et al. RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging. Prague, Czech Republic: IEEE; 2013. p. 397–400.Google Scholar
  47. 47.
    Goertz RS, Egger C, Neurath MF, Strobel D. Impact of food intake, ultrasound transducer, breathing maneuvers and body position on acoustic radiation force impulse (ARFI) elastometry of the liver. Ultraschall Med. 2012;33:380–5.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Mederacke I, Wursthorn K, Kirschner J, et al. Food intake increases liver stiffness in patients with chronic or resolved hepatitis C virus infection. Liver Int. 2009;29:1500–6.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Goertz RS, Zopf Y, Jugl V, et al. Measurement of liver elasticity with acoustic radiation force impulse (ARFI) technology: an alternative noninvasive method for staging liver fibrosis in viral hepatitis. Ultraschall Med. 2010;31:151–5.PubMedCrossRefGoogle Scholar
  50. 50.
    Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol. 2003;29:1705–13.PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Fraquelli M, Rigamonti C, Casazza G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut. 2007;56:968–73.PubMedPubMedCentralCrossRefGoogle Scholar
  52. 52.
    Kim BK, Fung J, Yuen MF, Kim SU. Clinical application of liver stiffness measurement using transient elastography in chronic liver disease from longitudinal perspectives. World J Gastroenterol. 2013;19:1890–900.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Woo Kyoung Jeong
    • 1
  1. 1.Department of Radiology and Center for Imaging Science, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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