Liver Diseases pp 427-441 | Cite as

Noninvasive Biomarkers for Liver Fibrosis

  • Gamal Shiha
  • Nasser Mousa


Fibrosis is a serious problem of chronic liver diseases. Liver fibrosis occurs as a response to different causes of chronic liver diseases. The diagnosing of the degree of liver fibrosis is an essential step in the assessment of the severity of the liver disease and is important for better patient care. The reference method for diagnosis and staging of liver fibrosis is liver biopsy, but it is invasive with many complications and limitations. Up to date, many non-invasive direct or indirect serum markers representing the activity of fibrogenesis have been developed. The direct biomarkers are a mirror of extracellular matrix turnover and indirect markers reflect the hepatocellular dysfunction. These markers may be used single or, in conjugation with each other. The major objective of this review is to understand the diagnostic accuracy, advantages and disadvantages of non-invasive biomarkers and scoring systems currently being used for studying liver fibrosis.


Liver fibrosis Noninvasive serum markers Liver biopsy Extracellular matrix 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Gamal Shiha
    • 1
    • 2
  • Nasser Mousa
    • 3
  1. 1.Department of Internal Medicine and HepatologyMansoura UniversityMansouraEgypt
  2. 2.Egyptian Liver Research Institute and Hospital (ELRIH), SherbinEl-MansouraMansouraEgypt
  3. 3.Departments of Tropical MedicineMansoura UniversityMansouraEgypt

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