Non-B/non-C viral hepatitis can be caused by the three well characterized hepatotropic viruses: hepatitis A virus (HAV), hepatitis delta virus (HDV) and hepatitis E virus (HEV). Their epidemiology as well as their pathogenesis have been studied in great detail. Further, the structure and genetic organization of their RNA genomes including the viral life cycle have been elucidated. These discoveries have been successfully translated into important clinical applications, such as the specific diagnosis, therapy and prevention of the associated liver diseases, including acute or fulminant hepatitis as well as for chronic hepatitis D and E, respectively, their long-term sequelae liver cirrhosis and hepatocellular carcinoma (HCC).
KeywordsHepatitis A Hepatitis D Hepatitis E
Conflict of interests: The author declares no conflict of interest.
Financial disclosure: The author has no financing to disclose.
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