Liver Diseases pp 107-116 | Cite as

Acquired Metabolic Disorders

  • Ivanesa L. Pardo Lameda
  • Timothy R. KochEmail author


The liver is a complex and critically important organ involved in both the biosynthesis of as well as the metabolism of numerous biochemical products. Acquired metabolic liver disorders result from the loss of this hepatic homeostasis. It is thought that the first recognition of a metabolic liver disorder was the description of porphyria by Hippocrates. The focus of this chapter is the potential origins for, diagnosis of, and treatment of acquired metabolic liver disorders, which include ornithine transcarbamylase deficiency, porphyria, hemochromatosis, and alpha 1 antitrypsin deficiency. Origins for acquired metabolic liver disorders include bariatric surgery with regards to ornithine transcarbamylase deficiency, organic chemical exposure with regards to porphyria, alcohol use/repeated blood transfusions/excessive oral iron supplements/hepatitis C with regards to hemochromatosis, and infectious Tropical Pulmonary Eosinophilia with regards to alpha 1 antitrypsin deficiency. Wilson disease is an additional, important genetic metabolic liver disease. In future work, pathophysiological mechanisms of disease and preventing the development of acquired metabolic liver disorders remain areas of focus for clinical research in this field.


Metabolic disease Ornithine transcarbamylase deficiency Hemochromatosis Porphyria Wilson disease Alpha 1 antitrypsin deficiency 


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Further Readings

    Ornithine Transcarbamylase Deficiency

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    Alpha 1 Antitrypsin Deficiency

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Center for Advanced Laparoscopic General & Bariatric SurgeryWashington, DCUSA
  2. 2.MedStar Washington Hospital Center and Georgetown University School of MedicineWashington, DCUSA

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