Role of Heat Shock Proteins in Brain Tumors

  • George A. Alexiou
Part of the Heat Shock Proteins book series (HESP, volume 20)


Heat shock proteins (HSP) constitute a major focus of cancer research. HSP have been found to be elevated in many human cancers and their expression has been related to patients’ prognosis. GBM is the most common primary malignant brain tumor with dismal prognosis. HSP have attracted a major interest as important anti-cancer targets since they have been implicated in glioma growth, invasion, angiogenesis and resistance to treatment. HSP inhibitors and vaccines are currently tested as new agents for brain tumors treatment.


Brain tumor Glioma Heat shock proteins Inhibitors Medulloblastoma Vaccines 





Hypoxia-inducible factor-1


Heat shock protein


Heat shock protein-peptide complex-96




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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • George A. Alexiou
    • 1
  1. 1.Department of Neurosurgery, School of MedicineUniversity of IoanninaIoanninaGreece

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