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Role of HSP in the Treatment of Internal Diseases

  • Ozden Yildirim Akan
  • Pinar Ortan
  • Ferda Hosgorler
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 20)

Abstract

Heat shock proteins (HSP) take their name from their apparent accidental discovery following transient heat stress in the salivary glands of Drosophila melanogaster (5 °C above normal temperature) HSP. All cells, from bacteria to human, have a common, complicated response to stress that protects them from injury. HSP play a major role in that response. HSP, protect the structure of normal proteins and plays a role in repairing or removing damaged ones. HSP response shows similar effects when faced with stressor conditions, such as oxidative stress, glucose deprivation, and infection, which lead to the misfolding of intracellular proteins. HSP participate in protein prevention from denaturation, repair, degradation of non-repairable ones, cell signal and response formation in the stress situations. Because of their important function in both physiological and pathological fields, it is possible to develop treatment strategies in many areas related to internal medicine. Current Data strongly supports efforts to target HSP in many diseases, mostly oncology. Drugs that make chaperone antagonism, such as Hsp90 inhibitors, reverse the damage caused by overexpressed HSP by helping to break down oncogenes. Treatment with HSP vaccines or HSP antagonists are in phase III trials in both inflammatory diseases and cancer treatment. Further studies will enable it to take its place in the treatment of inflammatory diseases and cancer.

Keywords

Apoptosis Cancer therapy Gastrointestinal disease Heat shock protein HSP vaccines Internal medicine 

Abbreviations

AGEs

advanced glycation end products

Apaf1

apoptotic protease activating factor 1

DED

death effector domain

eNOS

endothelial nitric oxide synthase

GGA

geranylgeranylacetone

GHRP-6

growth hormone releasing peptide-6

GM

geldanamycin

HSF

heat shock factor

HSP

heat shock proteins

HSPPC-96

heat shock protein-peptide complex-96

iNOS

inducible nitric oxide synthase

MHC

major histocompatibility complex

NO

nitric oxide

NOD2

nucleotide-binding oligomerization domain-containing protein 2

NSAID

non steroid antiinflammatory drug

NSCLC

non-small cell lung cancer

Pg

prostaglandin

RD

radicicol

ROS

reactive oxygen species

Tg2

tissue transglutaminase 2

TLR4

toll-like receptor 4

Tregs

regulatory T cells

WIS

water immersion stress

Notes

Acknowledgements

We want to thank Ozgur Golgelioglu for his help preparing the review.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ozden Yildirim Akan
    • 1
  • Pinar Ortan
    • 2
  • Ferda Hosgorler
    • 3
  1. 1.Division of İnternal MedicineSB University Izmir Bozyaka Training and Research HospitalIzmirTurkey
  2. 2.Division of NeurologySB University Izmir Bozyaka Training and Research HospitalIzmirTurkey
  3. 3.Division of PhysiologyDokuz Eylul University Medical FacultyİzmirTurkey

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