Early Mechanisms of Cardiac Development

  • Jack Griffiths
  • Thomas BrandEmail author
Part of the Learning Materials in Biosciences book series (LMB)


This chapter initially introduces the importance of animal models in understanding cardiac development. We will discuss the early stages of embryonic development, including gastrulation, formation of the linear heart tube and the looping process. We will then explore the concept of the organiser during early vertebrate development using the example of the Spemann-Mangold organiser of the amphibian embryo. Finally, we will expand on how cells in the embryo are able to interpret morphogen gradients by introducing the French Flag Model.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Imperial College LondonLondonUK
  2. 2.National Heart and Lung Institute, Myocardial Function, Imperial College LondonLondonUK

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