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Cellular and Molecular Mechanisms of Atherosclerosis

  • Adam Tsao
  • Mridul Rana
  • Joseph J. BoyleEmail author
Chapter
Part of the Learning Materials in Biosciences book series (LMB)

Abstract

This chapter will comprehensively discuss the underlying pathophysiology of atherosclerosis: a disease of global importance, focusing particularly on the role of immune and smooth muscle cells. We will then explore current research surrounding factors that may contribute to plaque instability and subsequent haemorrhage, including novel theories regarding the potential role of various macrophage subsets. Finally, we will examine atherosclerosis at a signalling level, expanding upon the role of inflammatory recruitment pathways and its constituent molecules.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Imperial College LondonLondonUK
  2. 2.National Heart and Lung Institute, Vascular Sciences, Imperial College LondonLondonUK

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