Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs

  • Samuel Guymer
  • Mayooran ShanmuganathanEmail author
Part of the Learning Materials in Biosciences book series (LMB)


This chapter will begin by briefly establishing the global clinical burden of heart failure (HF) and limitations of current treatment regimens. The use of left ventricular assist devices (LVADs) in advanced HF will then be explored, including a discussion of the underlying principles of mechanical unloading. We will then evaluate the emerging evidence of the role that exosomes and microRNAs may have in the diagnosis and treatment of cardiovascular diseases, including myocardial infarction.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.St George’s, University of LondonLondonUK
  2. 2.National Heart and Lung Institute, Myocardial FunctionImperial College LondonLondonUK
  3. 3.Cardiovascular Medicine, University of OxfordOxfordUK

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