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Tissue Sealants in Cardiac Surgery

  • Louis P. PerraultEmail author
  • Fatima Zohra Moukhariq
Chapter
  • 11 Downloads

Abstract

Significant bleeding is the most common surgical complication, occurring in up to 25% of all surgeries. Bleeding causes increased mortality and morbidity, by increasing the number of transfusions required, secondary to increased cumulative blood loss, and by causing hemodynamic instability. A solution to this issue encountered during surgery is the use of hemostatic products, tissue sealants, and adhesives. Worldwide, the number of topical adhesives, surgical sealants, and hemostats approved for use in the surgical setting is ever expanding. The objectives of this chapter are to review the spectrum of haemostats, sealants and adhesives products available in cardiovascular surgery and to provide an update on new products to be soon available, or in development, for reducing bleeding during surgical procedures.

Keywords

Adhesives Fibrin sealants Cardiac surgery Hemostatic agents Tissue sealants 

References

  1. 1.
    Rogers AC, Turley LP, Cross KS, McMonagle MP. Meta-analysis of the use of surgical sealants for suture-hole bleeding in arterial anastomoses. Br J Surg. 2016;103:1758–67.CrossRefGoogle Scholar
  2. 2.
    Forcillo J, Perrault LP. Armentarium of topical hemostatic products in cardiovascular surgery: an update. Transfus Apher Sci. 2014;50:26–31.CrossRefGoogle Scholar
  3. 3.
    Wan Y, Lim S, Gao X, et al. Bleeding-related complications and readmission rates associated with fibrin sealant use in patients undergoing coronary artery bypass graft surgery in the United States. J Cardiothorac Vasc Anesth. 2017;31:876–82.CrossRefGoogle Scholar
  4. 4.
    Carvalho MVH, Marchi E, Lourenço EA. Comparison of arterial repair through the suture, suture with fibrin or cyanoacrylate adhesive in ex-vivo porcine aortic segment. Braz J Cardiovasc Surg. 2017;32:487–91.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Duarte AP, Coelho JF, Bordado JC, et al. Surgical adhesives: systematic reviews of the main types and development forecast. Prog Polym Sci. 2012;37:1031–50.CrossRefGoogle Scholar
  6. 6.
    Bryan A, et al. Current issue in cardiovascular surgery. 2001. https://www.medscape.org/viewarticle/412896. Accessed 08 June 2018.
  7. 7.
    Bracey A, Shander A, Aronson S, et al. The use of topical hemostatic agents in cardiothoracic surgery. Ann Thorac Surg. 2017;104:353–60.CrossRefGoogle Scholar
  8. 8.
    Camp MA. Hemostatic agents: a guide to safe practice for perioperative nurses. AORN J. 2014;100:132–44.CrossRefGoogle Scholar
  9. 9.
    Spotnitz WD, Burks S. Hemostats, sealants and adhesives II: update as well as how and when to use the components of the surgical toolbox. Clin Appl Thromb Hemost. 2010;16:497–514.CrossRefGoogle Scholar
  10. 10.
    Spotnitz WD, Burks S. Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. Transfusion. 2012;52:2243–53.CrossRefGoogle Scholar
  11. 11.
    Leonardi M, Cenni P, Simonetti L, et al. Glubran 2: a new acrylic glue for neurological endovascular use a complement histological study. Interv Neuroradiol. 2003;9:249–54.CrossRefGoogle Scholar
  12. 12.
    Tackett SM, Calcaterra D, Magee G, Lattouf OM. Real-world outcomes of hemostatic matrices in cardiac surgery. J Cardiothorac Vasc Anesth. 2014;28:1558–65.CrossRefGoogle Scholar
  13. 13.
    Barnard J, Millner R. A review of topical hemostatic agents for use in cardiac surgery. Ann Thorac Surg. 2009;88:1377–83.CrossRefGoogle Scholar
  14. 14.
    Spotnitz WD, Burks S. Hemostats, sealants, and adhesives: components of the surgical toolbox. Transfusion. 2008;48:1502–16.CrossRefGoogle Scholar
  15. 15.
    Petrie EM. Cyanoacrylate adhesives in surgical applications. In: Mittal KL, editor. Progress in adhesions and adhesives. Beverly, MA: Scrivener Publishing LLC; 2015. p. 245–98.CrossRefGoogle Scholar
  16. 16.
    De Carvalho M, Marchi E. Mechanism of action of topical hemostatic and adhesive tissue agents. Rev Med Minas Gerais. 2013;23:488–93.Google Scholar
  17. 17.
    Perrin BRM, Braccini M, Bidan CM, et al. Adhesion of surgical sealants used in cardiothoracic and vascular surgery. Int J Adhes Adhes. 2016;70:81–9.CrossRefGoogle Scholar
  18. 18.
    Ma WG, Ziganshin BA, Guo CF, et al. Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery? J Thorac Dis. 2017;9:2491–7.CrossRefGoogle Scholar
  19. 19.
    Weiner J, Widman S, Golek Z, Tranquilli M, Elefteriades JA. Role of bovine serum albumin-glutaraldehyde glue in the formation of anastomatic pseudoaneurysms. J Card Surg. 2011;26:79–81.CrossRefGoogle Scholar
  20. 20.
    Li J, Celiz AD, Yang J, Yang Q, et al. Tough adhesives for diverse wet surfaces. Science. 2017;357:378–81.CrossRefGoogle Scholar
  21. 21.
    Lumsden AB, Heyman ER, Closure Medical Surgical Sealant Study Group. Prospective randomized study evaluating an absorbable cyanoacrylate for use in vascular reconstructions. J Vasc Surg. 2006;44:1002–9.CrossRefGoogle Scholar
  22. 22.
    Engelman DT, et al. Addressing the imperative to evolve the hospital new product value analysis process. J Thorac Cardiovasc Surg. 2018;155(2):682–5.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Cardiac Surgery DepartmentMontreal Heart InstituteMontrealCanada
  2. 2.Department of Surgery and PharmacologyUniversité de MontréalMontrealCanada
  3. 3.Research CenterMontreal Heart Institute, Université de MontréalMontrealCanada

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