Locomotor System Disease

  • Sebahattin Yurdakul
  • Pietro Leccese


Joint involvement in Behçet syndrome (BS) occurs in half of the patients in the form of arthritis or arthralgia. Behçet himself described joint involvement in 1938, a year after the original description of the disease. It is usually mono- or oligoarticular and can be symmetrical when not monoarticular. The arthritis usually lasts a few weeks, and it seldom results in deformity and radiological erosions. Chronic arthritis is seen only occasionally. The most frequently involved joints are the knees, followed by ankles, wrists, elbows, and hands. Axial involvement in the form of spinal, shoulder, hip, and sacroiliac joints is rare. In addition, back pain is quite rare and controlled studies have not shown an increased sacroiliac joint involvement. Patients with BS and arthritis also have more acne lesions. Furthermore, patients with arthritis and acne lesions have significantly higher enthesopathy scores than patients without acne. This suggests a possible pathogenetic link with acne-associated arthritis. Laboratory features are generally nonspecific. The erythrocyte sedimentation rate and C-reactive protein may be mildly elevated, but these may not correlate with the severity of arthritic attacks. Autoantibodies like rheumatoid factor and antinuclear antibodies are absent. Synovial fluid is inflammatory with a predominance of polymorphonuclear leucocytes although it has a good mucin clot. Synovial histology shows nonspecific inflammation. Fibromyalgia can be associated with BS especially among the female patients. Generalized or localized myositis and osteonecrosis are infrequently seen.


Arthralgia Arthritis Azathioprine Anti-TNF drugs Behçet disease Behçet syndrome Colchicine Fibromyalgia Joint involvement Myositis Osteonecrosis Synovial fluid Synovial histology 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Sebahattin Yurdakul
    • 1
  • Pietro Leccese
    • 2
  1. 1.Department of Medicine, Division of Rheumatology, Cerrahpasa Medical FacultyUniversity of IstanbulIstanbulTurkey
  2. 2.Rheumatology Institute of Lucania (IRel) and Rheumatology Department of LucaniaSan Carlo Hospital of Potenza and Madonna delle Grazie Hospital of MateraPotenzaItaly

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