Effects of Soap-Water Wash on Human Epidermal Penetration
Epidermal penetration was assayed with four chemicals to elucidate the effect of SC hydration on chemical penetration. Results showed accelerated benzoic acid and paraoxon penetration quickly after surface wash, but reduced penetration of hydroquinone and benzoic acid 30 min postdecontamination. At the end of the experiment, lower hydroquinone penetration, greater paraoxon penetration, and similar levels of benzoic acid and clonidine penetration resulted from surface wash. The observed wash-in effect agrees with the enhancement effect of SC hydration on SC chemical absorption rate.
KeywordsSkin decontamination Percutaneous penetration Wash-in effect Pesticide Stratum corneum
This research is supported by Defense Threat Reduction Agency (DTRA) Grant: HDTRA1-14-0005 UCSF (BRBAA11-PerC-9-2-0054 – Base).
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