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Fertility Control in Wildlife: Review of Current Status, Including Novel and Future Technologies

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Reproductive Sciences in Animal Conservation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1200))

Abstract

Wildlife conservation requires varying degrees of management of endangered species as well as management of their potential predators and competitors. Conservation also depends on ameliorating human-wildlife conflict, especially where there is a threat to the safety of people and of their pets and livestock. In addition, sustainability of wildlife populations can be affected by feral domestic animals or invasive species, that require removal or control. With the increasing concern for animal welfare, non-lethal methods of limiting population size and distribution, such as fertility control, are gaining favor. Breeding programs in zoos depend on highly effective and selective contraception to manage sustainable insurance populations. This review covers fertility control methods currently in use, those that have not lived up to past promises, and others that are under development and present hope for addressing remaining challenges.

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References

  • Asa CS. Male reproductive success in free-ranging feral horses. Behav Ecol Sociobiol. 1999;47:89–93.

    Article  Google Scholar 

  • Asa CS, Zaneveld LJD, Munson L, Callahan M, Byers AP. Efficacy, safety, and efficacy of a bisdiamine male-directed oral contraceptive in gray wolves (Canis lupus). J Zoo Wildl Med. 1996;27:501–6.

    Google Scholar 

  • Asa CS, Porton IJ, Junge R. Reproductive cycles and contraception of black lemurs (Eulemur macaco macaco) with depot medroxyprogesterone acetate during the breeding season. Zoo Biol. 2007;26:289–98.

    Article  CAS  PubMed  Google Scholar 

  • Asa CS, Bauman KL, Devery S, Zordan M, Camilo GR, Boutelle S, Moresco A. Factors associated with uterine endometrial hyperplasia and pyometra in wild canids: implications for fertility. Zoo Biol. 2014;33:8–19.

    Article  PubMed  Google Scholar 

  • Attardi B. Progesterone modulation of the luteinizing hormone surge: regulation of hypothalamic and pituitary progestin receptors. Endocrinology. 1984;115:2113–22.

    Article  CAS  PubMed  Google Scholar 

  • Avery ML, Keacher KL, Tillman EA. Nicarbazin bait reduces reproduction by pigeons (Columba livia). Wildl Res. 2008a;35:80–5.

    Article  CAS  Google Scholar 

  • Avery ML, Yoder CA, Tillman EA. Diazacon inhibits reproduction in invasive monk parakeet populations. J Wildl Manag. 2008b;72:1449–52.

    Article  Google Scholar 

  • Baker DL, Wild MA, Conner MM, Ravivarapu HB, Dunn RL, Nett TM. Effects of GnRH agonist (leuprolide) on reproduction and behaviour in female wapiti (Cervus elaphus nelsoni). Reprod Suppl. 2002;60:155–67.

    CAS  PubMed  Google Scholar 

  • Baker DL, Wild MA, Connor MM, Ravivarapu HB, Dunn RL, Nett TM. Gonadotropin-releasing hormone agonist: a new approach to reversible contraception in female deer. J Wildl Dis. 2004;40:713–24.

    Article  CAS  PubMed  Google Scholar 

  • Baker DL, Wild MA, Hussain MD, Dunn RL, Nett TM. Evaluation of remotely delivered leuprolide acetate as a contraceptive agent in female elk (Cervus elaphus nelsoni). J Wildl Dis. 2005;41:758–67.

    Article  CAS  PubMed  Google Scholar 

  • Baldwin CJ, Peter AT, Bosu W, Dubielzig RR. The contraceptive effects of levonorgestrel in the domestic cat. Lab Anim Sci. 1994;44:261–9.

    CAS  PubMed  Google Scholar 

  • Ball BA, Sabeur K, Nett T, Liu IKM. Effects of a GnRH cytotoxin on reproductive function in peripubertal male dogs. Theriogenology. 2006;66:766–74.

    Article  CAS  PubMed  Google Scholar 

  • Balser DS. Management of predator populations with antifertility agents. J Wildl Manag. 1964;28:352–8.

    Article  Google Scholar 

  • Bechert U, Fraker MA. The response of African elephants to a single-dose of SpayVac, a pZP contraceptive vaccine, over a 7-year period. Pachyderm. 2016;57:97–108.

    Google Scholar 

  • Bechert U, Fraker MA. Twenty years of SpayVac research: potential implications for regulating feral horse and burro populations in the United States. Hum Wildl Interact. 2018;12:117–20.

    Google Scholar 

  • Bechert U, Bartell J, Kutzler M, Menino A, Bildfell R, Anderson M, Fraker M. Effects of two porcine zona pellucida immunocontraceptive vaccines on ovarian activity in horses. J Wildl Manag. 2013;77:1386–400.

    Article  Google Scholar 

  • Beijerink NJ, Buijtels JJ, Okkens AC, Kooistra HS, Dieleman SJ. Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches. Theriogenology. 2007;67:1039–45.

    Article  CAS  PubMed  Google Scholar 

  • Bertschinger HJ, Asa CS, Calle PP, Long JA, Bauman K, DeMatteo K, Jochle W, Trigg TE, Human A. Control of reproduction and sex related behaviour in exotic wild carnivores with the GnRH analogue deslorelin: preliminary observations. J Reprod Fertil Suppl. 2001;57:275–83.

    CAS  PubMed  Google Scholar 

  • Bertschinger H, de Barros Vaz Guimarães MA, Trigg T, Human A. The use of deslorelin implants for the long-term contraception of lionesses and tigers. Wildl Res. 2008;35:525–30.

    Article  CAS  Google Scholar 

  • Beyler AL, Poots GO, Coulston F, Surrey AR. The selective testicular effects of certain bis(dichloroacetyl)diamines. Endocrinology. 1961;69:819–33.

    Article  CAS  Google Scholar 

  • Binder M. The teratogenic effects of a bis (dichloroacetyl) diamine on hamster embryos. Aortic arch anomalies and the pathogenesis of the DiGeorge syndrome. Am J Pathol. 1985;118:179.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Biquand S, Boug A, Biquand-Guyot V, Gautier J-P. Management of commensal baboons in Saudi Arabia. Revue d’Ecologie. 1994;49:213–22.

    Google Scholar 

  • Bishop CC, Fleming PA, Barnes AL, Collins T, Miller DW. Immunisation against gonadotrophin-releasing hormone (GnRH) reduces agonistic behaviours in male rangeland goats. Anim Prod Sci. 2016;56:1882–7.

    Article  CAS  Google Scholar 

  • Brache V, Faundes A, Johansson E. Anovulation, inadequate luteal phase and poor sperm penetration in cervical mucus during prolonged use of Norplant implants. Contraception. 1985;31:261–73.

    Article  CAS  PubMed  Google Scholar 

  • Bromley C, Gese EM. Surgical sterilization as a method of reducing coyote predation on domestic sheep. J Wildl Manag. 2001a;65:510–9.

    Article  Google Scholar 

  • Bromley D, Gese EM. Effects of sterilization on territory fidelity and maintenance, pair bonds, and survival rates of free-ranging coyotes. Can J Zool. 2001b;79:386–92.

    Article  Google Scholar 

  • Brown RG, Bowen WD, Eddington JD, Kimmins WC, Mezei M, Parsons JL, Pohajdak B. Evidence for a long-lasting single administration contraceptive vaccine in wild grey seals. J Reprod Immunol. 1997;35:43–51.

    Article  CAS  PubMed  Google Scholar 

  • Cagnacci F, Massei G, Cowan DP, Walker N, Delahay RJ. Effects of bait type and deployment strategy on uptake by free-living badgers. Wildl Res. 2007;34:454–60.

    Article  Google Scholar 

  • Calle PP. Contraception in pinnipeds and cetaceans. In: Asa CS, Porton IJ, editors. Wildlife contraception: issues, methods and applications. Baltimore: Johns Hopkins University Press; 2005. p. 168–76.

    Google Scholar 

  • Campbell TA, Long DB, Massei G. Efficacy of the boar-operated-system to deliver baits to feral swine. Prev Vet Med. 2011;98:243–9.

    Article  PubMed  Google Scholar 

  • Cheng CY, Mruk DD. New frontiers in nonhormonal male contraception. Contraception. 2010;82:476–82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chuei JY, Asa CS, Hall-Woods M, Ballou J, Traylor-Holzer K. Restoration of reproductive potential after expiration or removal of melengestrol acetate contraceptive implants in tigers (Panthera tigris). Zoo Biol. 2007;26:275–88.

    Article  PubMed  Google Scholar 

  • Cope HR, Hogg CJ, White PJ, Herbert CA. A role for selective contraception of individuals in conservation. Conserv Biol. 2018;32:546–58.

    Article  PubMed  Google Scholar 

  • Cowan ML, Martin GB, Monks DJ, Johnston SD, Doneley RJT, Blackberry MA. Inhibition of the reproductive system by deslorelin in male and female pigeons (Columba livia). J Avian Med Surg. 2014;28:102–8.

    Article  PubMed  Google Scholar 

  • Cowl VB, Walker SL, Feltrer Rambaud Y. Assessing the efficacy of deslorelin acetate implants (Suprelorin) in alternative placement sites. J Zoo Wildl Med. 2018;49:1–8.

    Article  PubMed  Google Scholar 

  • Curtis P, Pooler R, Richmond M, Miller L, Mattfeld G, Quimby F. Comparative effects of GnRH and porcine zona pellucida (PZP) immunocontraceptive vaccines for controlling reproduction in white-tailed deer (Odocoileus virginianus). Reprod Suppl. 2002;60:131–41.

    CAS  PubMed  Google Scholar 

  • de Oliveira CA, West GD, Houck R, Leblanc M. Control of musth in an Asian elephant bull (Elephas maximus) using leuprolide acetate. J Zoo Wildl Med. 2004;35:70–6.

    Article  PubMed  Google Scholar 

  • Davis KA, Klohonatz KM, Mora DS, Twenter HM, Graham PE, Pinedo P, Eckery DC, Bruemmer JE. Effects of immunization against bone morphogenetic protein-15 and growth differentiation factor-9 on ovarian function in mares. Anim Reprod Sci. 2018;192:69–77.

    Article  CAS  PubMed  Google Scholar 

  • DeMatteo KE. Contraception in carnivores. In: Asa CS, Porton IJ, editors. Wildlife contraception: issues, methods, and applications. Baltimore: Johns Hopkins University Press; 2005. p. 105–18.

    Google Scholar 

  • DeNicola AJ, Kesler DJ, Swihart RK. Dose determination and efficacy of remotely delivered norgestomet implants on contraception of white-tailed deer. Zoo Biol. 1997;16:31–8.

    Article  CAS  Google Scholar 

  • Drobeck HP, Coulston F. Inhibition and recovery of spermatogenesis in rats, monkeys and dogs medicated with bis(dichloroacetyl)diamines. Exp Mol Pathol. 1962;1:251–74.

    Article  CAS  PubMed  Google Scholar 

  • Dunbar BS, Lo C, Powell J, Stevens VC. Use of a synthetic peptide adjuvant for the immunization of baboons with denatured and deglycosylated pig zona pellucida glycoproteins. Fertil Steril. 1989;52:311–8.

    Article  CAS  PubMed  Google Scholar 

  • Duncan GL, Lyster SC, Hendrix JW, Clark JJ, Webster HD. Biologic effects of melengestrol acetate. Fertil Steril. 1964;15:419–32.

    Article  Google Scholar 

  • Dunshea F, King R, Campbell R, Sainz R, Kim Y. Growth performance, carcass characteristics and meat quality of group-penned surgically castrated, immunocastrated (Improvac®) and entire male pigs and individually penned entire male pigs. J Anim Sci. 1993;71:2913–30.

    Google Scholar 

  • Eagle TC, Plotka ED, Siniff DB, Tester JR. Efficacy of chemical contraception in feral mares. Wildl Soc Bull. 1992;20:211–6.

    Google Scholar 

  • Eagle T, Asa CS, Garrott R, Siniff DV. Efficacy of dominant male contraception to reduce reproduction in feral horses. Wildl Soc Bull. 1993;21:116–21.

    Google Scholar 

  • Eckery DC, Miller LA, Killian GJ, DeNicola AJ. Effect of vaccination against GDF9 and BMP15 on fertility and ovarian function in white-tailed deer. In: Timm RM, O’Brien JM, editors. Proceedings 26th vertebrate pest conference. Davis: University of California-Davis; 2014. p. 391–5.

    Google Scholar 

  • Eisemann JD, Fagerstone KA, O’Hare JR. Wildlife contraceptives: a regulatory hot potato. In: Timm RM, O’Brien JM, editors. Proc 22nd vertebrate pest conference. Berkeley: University of California-Davis; 2006. p. 63–6.

    Google Scholar 

  • Eisemann JD, O’Hare JR, Fagerstone KA. State-level approaches to managing the use of contraceptive in wildlife in the United States. J Zoo Wildl Med. 2013;44:S47–51.

    Article  PubMed  Google Scholar 

  • Evans JM, Sutton DJ. The use of hormones, especially progestagens, to control oestrus in bitches. J Reprod Fertil Suppl. 1989;39:163–73.

    CAS  PubMed  Google Scholar 

  • Fagerstone KA, Miller LA, Killian G, Yoder CA. Review of issues concerning the use of reproductive inhibitors, with particular emphasis on resolving human-wildlife conflicts in North America. Integr Zool. 2010;5:15–30.

    Article  PubMed  Google Scholar 

  • Fagundes AKF, Oliveira ECS, Tenorio BM, Melo CCS, Nery LTB, Santos FAB, Alves LC, Douglas RH, Silva VA. Injection of a chemical castration agent, zinc gluconate, into the testes of cats results in the impairment of spermatogenesis: a potentially irreversible contraceptive approach for this species? Theriogenology. 2014;81(2):230–6.

    Article  CAS  PubMed  Google Scholar 

  • Fayrer-Hosken RA, Bertschinger HJ, Kirkpatrick JF, Grobler D, Lamberski N, Honneyman G, Ulrich T. Contraceptive potential of the porcine zona pellucida vaccine in the African elephant (loxodonta africana). Theriogenology. 1999;52(5):835–46.

    Article  CAS  PubMed  Google Scholar 

  • Fekete G, Szeberényi S. Data on the mechanism of adrenal suppression by medroxyprogesterone acetate. Steroids. 1965;6:159–66.

    Article  CAS  PubMed  Google Scholar 

  • Fischer A, Benka VA, Briggs J, Driancourt M-A, Maki J, Mora DS, Morris K, Myers KA, Rhodes L, Vansandt LM, Weedon GR, Wolf J, Levy JK. Effectiveness of GonaCon as an immunocontraceptive in colony-housed cats. J Feline Med Surg. 2018;20:786–92.

    Article  PubMed  Google Scholar 

  • Fraker MA, Brown RG, Grant GE, Kerr JA, Pohajdak B. Long-lasting, single dose, immunocontraception of feral fallow deer in British Columbia. J Wildl Manag. 2002;66:1141–7.

    Article  Google Scholar 

  • Frank KM, Lyda RO, Kirkpatrick JF. Immunocontraception of captive exotic species. IV. Species differences in response to the porcine zona pellucida vaccine, timing of booster inoculations and procedural failures. Zoo Biol. 2005;24:349–58.

    Article  Google Scholar 

  • Garrett MG, Franklin WL. Diethylstilbestrol as a temporary chemosterilant to control black-tailed prairie dog populations. J Range Manag. 1983;36:753–6.

    Article  Google Scholar 

  • Garrott RA, Oli MK. A critical crossroad for BLM’s wild horse program. Science. 2013;341:847–8.

    Article  CAS  PubMed  Google Scholar 

  • Garside D, Gebril A, Alsaadi M, Ferro VA. Fertility control in wildlife: review of current status, including novel and future technologies. In: Holt WV, Brown JL, Comizzoli P, editors. Reproductive sciences in animal conservation: advances in experimental medicine and biology. New York: Springer; 2014. p. 467–88.

    Google Scholar 

  • Gee EK, DeLuca C, Stylski JL, McCue PM. Efficacy of medroxyprogesterone acetate in suppression of estrus in cycling mares. J Equine Vet Sci. 2009;29:140–5.

    Article  Google Scholar 

  • Gionfriddo JP, Gates NB, DeNicola AJ, Fagerstone KA, Miller LA. Field test of GonaCon™ immunocontraceptive vaccine in free-ranging female fallow deer. In: Timm RM, Modon MB, editors. Proc 23rd vertebrate pest conference. Davis: University of California-Davis; 2008.

    Google Scholar 

  • Gionfriddo JP, DeNicola AJ, Miller LA, Fagerstone KA. Health effects of GnRH immunocontraception of wild white-tailed deer in New Jersey. Wildl Soc Bull. 2011;35:149–60.

    Article  Google Scholar 

  • Goblet CC, Moresco A, Garner MM, Agnew DW, Newell-Fugate AE. Retrospective characterization of reproductive tract lesions in relation to age, parity, and contraception in captive suidae and tayassuidae. Theriogenology. 2019;127:137–44.

    Article  PubMed  Google Scholar 

  • Goericke-Pesch S, Georgiev P, Antonov A, Albouy M, Wehrend A. Clinical efficacy of a GnRH-agonist implant containing 4.7mg deslorelin, Suprelorin, regarding suppression of reproductive function in tomcats. Theriogenology. 2011;75:803–10.

    Article  CAS  PubMed  Google Scholar 

  • Gulyas BJ, Gwatkin RBL, Yuan LC. Active immunization of cynomolgus monkeys (Macaca fascicularis) with porcine zonae pellucidae. Gamete Res. 1983;4:299–307.

    Article  Google Scholar 

  • Halpern V, Stalter RM, Owen DH, Dorflinger LJ, Lendvay A, Rademacher KH. Towards the development of a longer-acting injectable contraceptive: past research and current trends. Contraception. 2015;92:3–9.

    Article  CAS  PubMed  Google Scholar 

  • Hapgood JP, Koubovec D, Louw A, Africander D. Not all progestins are the same: implications for usage. Trends Pharmacol Sci. 2004;25:554–7.

    Article  CAS  PubMed  Google Scholar 

  • Hay BA, Li J, Guo M. Vectored gene delivery for lifetime animal contraception: overview and hurdles to implementation. Theriogenology. 2018;112:63–74.

    Article  CAS  PubMed  Google Scholar 

  • Heller CG, Moore DJ, Paulsen CA. Suppression of spermatogenesis and chronic toxicity in men by a new series of bis (dichloroacetyl) diamines. Toxicol Appl Pharmacol. 1961;3:1–11.

    Article  CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg TE. Applications of GnRH in the control and management of fertility in female animals. Anim Reprod Sci. 2005;88:141–53.

    Article  CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg T, Cooper DW. Effect of deslorelin implants on follicular development, parturition and post-partum oestrus in the tammar wallaby (Macropus eugenii). Reproduction. 2004;127:265–73.

    Article  CAS  PubMed  Google Scholar 

  • Herbert CA, Trigg TE, Renfree MB, Shaw G, Eckery DC, Cooper DW. Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii). Reproduction. 2005;129:361–9.

    Article  CAS  PubMed  Google Scholar 

  • Hermes R, Schwarzenberger F, Göritz F, Oh S, Fernandes T, Bernardino R, Leclerc A, Greunz E, Mathew A, Forsyth S, Saragusty J, Hildebrandt TB. Ovarian down regulation by GnRF vaccination decreases reproductive tract tumour size in female white and greater one-horned rhinoceroses. PLoS One. 2016;11:e0157963.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hidiroglou M, Knipfel JE. Zinc in mammalian sperm: a review. J Dairy Sci. 1984;67:1147–56.

    Article  CAS  PubMed  Google Scholar 

  • Hild SA, Meistrich ML, Blye RP, Reel JR. Lupron depot prevention of anti-spermatogenic/antifertility activity of the indenopyridine, CDB-4022, in the rat. Biol Reprod. 2001a;65:165–72.

    Article  CAS  PubMed  Google Scholar 

  • Hild SA, Reel JR, Larner JM, Blye RP. Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats. Reproduction. 2001b;65:1771–9.

    Article  CAS  Google Scholar 

  • Hild SA, Marshall GR, Attardi BJ, Hess RA, Schlatt S, Simorangkir DR, Ramaswamy S, Koduri S, Reel JR, Plant TM. Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). Endocrinology. 2007;148:1784–96.

    Article  CAS  PubMed  Google Scholar 

  • Hobbs NT, Bowden DC, Baker DL. Effects of fertility control on populations of ungulates: general, stage-structured models. J Wildl Manag. 2000;64:473–91.

    Article  Google Scholar 

  • Hodel C, Suter K. Reversible inhibition of spermatogenesis with an indenopyridine (20-438). Arch Toxicol Suppl. 1978;1:323–6.

    Article  Google Scholar 

  • Hone J. Rate of increase and fertility control. J Appl Ecol. 1992;29:695–8.

    Article  Google Scholar 

  • Hone J. On rate of increase (r): patterns of variation in Australian mammals and the implications for wildlife management. J Appl Ecol. 1999;36:709–18.

    Article  Google Scholar 

  • Hynes EF, Handasyde KA, Shaw G, Renfree MB. The effects of gestagen implants on the behaviour of free-ranging female koalas. Appl Anim Behav Sci. 2011;134:209–16.

    Article  Google Scholar 

  • Ibrahim A, Ali MM, Abou-Khalil NS, Ali MF. Evaluation of chemical castration with calcium chloride versus surgical castration in donkeys: testosterone as an endpoint marker. BMC Vet Res. 2016;12:46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jacobsen NK, Jessup DA, Kessler DJ. Contraception of captive black-tailed deer by remotely delivered norgestomet ballistic implants. Wildl Soc Bull. 1995;23:718–22.

    Google Scholar 

  • Jana K, Samanta PK. Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats. Contraception. 2006;73:289–300.

    Article  CAS  PubMed  Google Scholar 

  • Jana K, Samanta PK. Sterilization of male stray dogs with a single intratesticular injection of calcium chloride: a dose-dependent study. Contraception. 2007;75:390–400.

    Article  CAS  PubMed  Google Scholar 

  • Jana K, Samanta PK. Clinical evaluation of non-surgical sterilization of male cats with single intra-testicular injection of calcium chloride. BMC Vet Res. 2011;7:39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jana K, Samanta P, Ghosh D. Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization of male Black Bengal goats (Capra hircus): a dose-dependent study. Anim Reprod Sci. 2005;86:89–108.

    Article  CAS  PubMed  Google Scholar 

  • Jarosz SJ, Dukelow WR. Effect of progesterone and medroxyprogesterone acetate on pregnancy length and litter size in mink. Lab Anim Sci. 1985;35:156–8.

    CAS  PubMed  Google Scholar 

  • Joonè CJ, Bertschinger HJ, Gupta SK, Fosgate GT, Arukha AP, Minhas V, Dieterman E, Schulman ML. Ovarian function and pregnancy outcome in pony mares following immunocontraception with native and recombinant porcine zona pellucida vaccines. Equine Vet J. 2017a;49:189–95.

    Article  PubMed  Google Scholar 

  • Joonè CJ, Schulman ML, Bertschinger HJ. Ovarian dysfunction associated with zona pellucida–based immunocontraceptive vaccines. Theriogenology. 2017b;89:329–37.

    Article  PubMed  CAS  Google Scholar 

  • Juengel JL, Hudson NL, Heath DA, Smith P, Reader KL, Lawrence SB, O’Connell AR, Laitinen MPE, Cranfield M, Groome NP, Ritvos O, McNatty KP. Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep1. Biol Reprod. 2002;67:1777–89.

    Article  CAS  PubMed  Google Scholar 

  • Juengel JL, Hudson NL, Berg M, Hamel K, Smith P, Lawrence SB, Whiting L, McNatty KP. Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle. Reproduction. 2009;138:107.

    Article  CAS  PubMed  Google Scholar 

  • Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. PNAS. 2017;114:E1688–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kazensky CA, Munson L, Seal US. The effects of melengestrol acetate on the ovaries of captive wild felids. J Zoo Wildl Med. 1998;29:1–5.

    CAS  PubMed  Google Scholar 

  • Kellokumpu S, Rajaniemi H. Effect of zinc on the uptake of human chorionic gonadotropin (hCG) in rat testis and testosterone response in vivo. Biol Reprod. 1981;24:298.

    Article  CAS  PubMed  Google Scholar 

  • Killian G, Miller L, Rhyan J, Dees T, Perry D, Doten H. Evaluation of GnRH contraceptive vaccine in captive feral swine in Florida. In: Fagerstone KA, Witmer GW, editors. Proc 10th wildlife damage management conf; 2003. p. 128–33.

    Google Scholar 

  • Killian G, Diehl NK, Miller LA, Rhyan J, Thain D. Long-term efficacy of three contraceptive approaches for population control of wild horses. Proc Vertebr Pest Conf. 2006;22.

    Google Scholar 

  • Killian G, Wagner D, Fagerstone K, Miller L. Long-term efficacy and reproductive behavior associated with GonaCon(R) use in white-tailed deer (Odocoileus virginianus). In: Timm RM, editor. Proc 23rd vertebrate pest conference. Davis: University of California-Davis; 2008. p. 240–3.

    Google Scholar 

  • Killian G, Kreeger TJ, Rhyan J, Fagerstone K, Miller L. Observations on the use of GonaCon™ in captive female elk (Cervus elaphus). J Wildl Dis. 2009;45:184–8.

    Article  PubMed  Google Scholar 

  • Kirkpatrick JF, Liu IMK, Turner JW, Naugle R, Keiper R. Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus). Reproduction. 1992;94(2):437–44.

    Article  CAS  Google Scholar 

  • Kirkpatrick JF, Turner A. Immunocontraception and increased longevity in equids. Zoo Biol. 2007;26:237–44.

    Article  PubMed  Google Scholar 

  • Kirkpatrick JF, Lyda R, Frank KM. Contraceptive vaccines for wildlife: a review. Am J Reprod Immunol. 2011;66:40–50.

    Article  PubMed  Google Scholar 

  • Kloosterboer HJ, Vonk-Noordegraaf CA, Turpijn EW. Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. Contraception. 1988;38:325–32.

    Article  CAS  PubMed  Google Scholar 

  • Knowlton FF, Gese EM, Jaeger MM. Coyote depredation control: an interface between biology and management. J Range Manag. 1999;52:398–412.

    Article  Google Scholar 

  • Koeppel KN, Barrows M, Visser K. The use of the gonadotropin-releasing hormone analog deslorelin for short-term contraception in red pandas (Ailurus fulgens). Theriogenology. 2014;81:220–4.

    Article  CAS  PubMed  Google Scholar 

  • Kutzler MA. Intratesticular and intraepididymal injections to sterilize male cats: from calcium chloride to zinc gluconate and beyond. J Feline Med Surg. 2015;17:772–6.

    Article  PubMed  Google Scholar 

  • Labrie C, Cusan L, Plante M, Lapointe S, Labrie F. Analysis of the androgenic activity of synthetic “progestins” currently used for the treatment of prostate cancer. J Steroid Biochem. 1987;28:379–84.

    Article  CAS  PubMed  Google Scholar 

  • Larson S, Belting T, Rifenbury K, Fisher G, Boutelle SM. Preliminary findings of fecal gonadal hormone concentrations in six captive sea otters (Enhydra lutris) after deslorelin implantation. Zoo Biol. 2013;32:307–15.

    Article  CAS  PubMed  Google Scholar 

  • Levy JK, Friary JA, Miller LA, Tucker SJ, Fagerstone KA. Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive. Theriogenology. 2011;76:1517–25.

    Article  CAS  PubMed  Google Scholar 

  • Li J, Olvera AI, Akbari OS, Moradian A, Sweredoski MJ, Hess S, Hay BA. Vectored antibody gene delivery mediates long-term contraception. Curr Biol. 2015;25:R820–2.

    Article  CAS  PubMed  Google Scholar 

  • Linhart SB, Enders RK. Some effects of diethylstilbestrol on reproduction in captive red foxes. J Wildl Manag. 1964;28:358–63.

    Article  CAS  Google Scholar 

  • Liu IKM, Bernoco M, Feldman M. Contraception in mares heteroimmunized with pig zona pellucidae. J Reprod Fertil. 1989;85:19–28.

    Article  CAS  PubMed  Google Scholar 

  • Lofts B, Murton RK, Thearle RJP. The effects of 22,25-diazacholesterol dihydrochloride on the pigeon testis and on reproductive behaviour. Reproduction. 1968;15(1):145–8.

    Article  CAS  Google Scholar 

  • Lohr CA, Mills H, Robertson H, Bencini R. Deslorelin implants control fertility in urban brushtail possums (Trichosurus vulpecula) without negatively influencing their body-condition index. Wildl Res. 2009;36:324–32.

    Article  CAS  Google Scholar 

  • Long J, Nand AV, Ray S, Mayhew S, White D, Bunt CR, Seyfoddin A. Development of customised 3D printed biodegradable projectile for administrating extended-release contraceptive to wildlife. Int J Pharm. 2018;548:349–56.

    Article  CAS  PubMed  Google Scholar 

  • Lueders I, Hildebrandt TB, Gray C, Botha S, Rich P, Niemuller C. Supression of testicular function in a male Asian elephant (Elephas maximus) treated with gonadotropin-releasing hormone vaccines. J Zoo Wildl Med. 2014;45:611–9.

    Article  PubMed  Google Scholar 

  • Lueders I, Young D, Maree L, Van der Horst G, Luther I, Botha S, Tindall B, Fosgate G, Ganswindt A, Bertschinger HJ. Effects of GnRH vaccination in wild and captive African elephant bulls (Loxodonta africana) on reproductive organs and semen quality. PLoS One. 2017;12:e0178270.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lyda RO, Frank KM, Wallace R, Lamberski N, Kirkpatrick JF. Immunocontraception of captive exotic species: V. Prolonged antibody titers in Dall sheep (Ovis dalli dalli) and domestic goats (Capra hircus) immunized with porcine zona pellucida. J Zoo Wildl Med. 2013;44:S21–5.

    Article  PubMed  Google Scholar 

  • MacLean RA, Mathews NE, Grove DM, Frank ES, Paul-Murphy J. Surgical technique for tubal ligation in white-tailed deer (Odocoileus virginianus). J Zoo Wildl Med. 2006;37:354–61.

    Article  PubMed  Google Scholar 

  • Maijer AM, Semple S. Investigating potential effects of the contraceptive Implanon on the behavior of free-ranging adult female Barbary macaques. J Appl Anim Welf Sci. 2016;19:16–23.

    Article  CAS  PubMed  Google Scholar 

  • Malaivijitnond S, Hamada Y. Current situation and status of long-tailed macaques (Macaca fascicularis) in Thailand. Trop Nat Hist. 2008;8:185–204.

    Google Scholar 

  • Marais HJ, Hendrickson DA, Stetter M, Zuba JR, Penning M, Siegal-Willott J, Hardy C. Laparoscopic vasectomy in African savannah elephant (Loxodonta africana); surgical technique and results. J Zoo Wildl Med. 2013;44:S18–20.

    Article  PubMed  Google Scholar 

  • Massei G, Cowan D. Fertility control to mitigate human–wildlife conflicts: a review. Wildl Res. 2014;41:1–21.

    Article  Google Scholar 

  • Massei G, Cowan DP, Coats J, Gladwell F, Lane JE, Miller LA. Effect of the GnRH vaccine GonaCon on the fertility, physiology and behaviour of wild boar. Wildl Res. 2008;35:540–7.

    Article  CAS  Google Scholar 

  • Massei G, Koon K-K, Benton S, Brown R, Gomm M, Orahood DS, Pietravalle S, Eckery DC. Immunocontraception for managing feral cattle in Hong Kong. PLoS One. 2015;10:e0121598.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Matschke GH. Fertility control in white-tailed deer by steroid implants. J Wildl Manag. 1977a;41:731–5.

    Article  CAS  Google Scholar 

  • Matschke GH. Micro-encapsulated diethylstilbestrol as an oral contraceptive in white-tailed deer. J Wildl Manag. 1977b;41:87–91.

    Article  CAS  Google Scholar 

  • Matter BE, Jaeger I, Suter W, Tsuchimoto T, Deysenroth H. Actions of an antispermatogenic but non-mutagenic indenopyridine derivative in mice and Salmonella typhimurium. Mutat Res. 1979;66:113–27.

    Article  CAS  PubMed  Google Scholar 

  • McShea WJ, Monfort SL, Hakim S, Kirkpatrick J, Liu I, Turner JW Jr, Chassy L, Munson L. The effect of immunocontraception on the behavior and reproduction of white-tailed deer. J Wildl Manag. 1997;61:560–9.

    Article  Google Scholar 

  • Meadows KL, Li Y, Xu Q, Ayres S. A novel non-surgical method to reduce fertility using the rat as a model. Clin Theriogenol. 2019;11:31–41.

    Google Scholar 

  • Metrione LC, Verstegen JP, Heard DJ, Leblanc D, Walsh AL, Penfold LM. Preliminary evaluation of deslorelin, a GnRH agonist for contraception of the captive variable flying fox Pteropus hypomelanus. Contraception. 2008;78:336–45.

    Article  CAS  PubMed  Google Scholar 

  • Middleton DJ, Watson A, Howe C, Caterson I. Suppression of cortisol responses to exogenous adrenocorticotrophic hormone, and the occurrence of side effects attributable to glucocorticoid excess, in cats during therapy with megestrol acetate and prednisolone. C J Vet Res. 1987;51:60–5.

    CAS  Google Scholar 

  • Middleton DR, Walters B, Menkhorst P, Wright P. Fertility control in the koala, Phascolarctos cinereus: the impact of slow-release implants containing levonorgestrel or oestradiol on the production of pouch young. Wildl Res. 2003;30:207–12.

    Article  CAS  Google Scholar 

  • Millam JR, Finney HL. Leuprolide acetate can reversibly prevent egg laying in cockatiels (Nymphicus hollandicus). Zoo Biol. 1994;13:149–55.

    Article  CAS  Google Scholar 

  • Miller LA, Bynum K, Zemlick D. PZP immunocontraception in coyotes: a multi-year study with three vaccine formulations. In: Timm RM, O’Brien JM, editors. Proc 22nd vertebrate pest conf. Davis: University of California-Davis; 2006. p. 88–95.

    Google Scholar 

  • Miller LA, Johns BE, Killian GJ. Immunocontraception of white-tailed deer with GnRH vaccine. Am J Reprod Immunol. 2000;44:266–74.

    Article  CAS  PubMed  Google Scholar 

  • Miller L, Rhyan J, Killian G. Evaluation of GnRH contraceptive vaccine using domestic swine as a model for feral hogs. In: Proc 10th wildlife damage management conference; 2003.

    Google Scholar 

  • Miller LA, Rhyan JC, Drew M. Contraception of bison by GnRH vaccine: a possible means of decreasing transmission of brucellosis in bison. J Wildl Dis. 2004;40:725–30.

    Article  CAS  PubMed  Google Scholar 

  • Miller L, Killian G, Thain D, Diehl NK, Rhyan J. Four-year contraception rates of mares treated with single-injection porcine zona pellucida and GnRH vaccines and intrauterine devices. Wildl Res. 2008;35:531–9.

    Article  Google Scholar 

  • Miller LA, Fagerstone KA, Wagner DC, Killian GJ. Factors contributing to the success of a single-shot, multiyear PZP immunocontraceptive vaccine for white-tailed deer. Hum Wildl Confl. 2009;3:103–15.

    Google Scholar 

  • Miller S, Bissett C, Burger A, Courtenay B, Dickerson T, Druce D, Ferreira S, Funston P, Hofmeyr D, Kilian P. Management of reintroduced lions in small, fenced reserves in South Africa: an assessment and guidelines. Afr J Wildl Res. 2013;43:138–55.

    Article  Google Scholar 

  • Miller PS, Boone JD, Briggs JR, Lawler DF, Levy JK, Nutter FB, Slater M, Zawistowski S, Allen BL. Simulating free-roaming cat population management options in open demographic environments. PLoS One. 2014;9(11):e113553.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mok K-W, Mruk DD, Lie PP, Lui W-Y, Cheng CY. Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes. Reproduction. 2011;141:571–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mol JA, van Garderen E, Rutteman GR, Rijnberk A. New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. J Steroid Biochem Mol Biol. 1996;57:67–71.

    Article  CAS  PubMed  Google Scholar 

  • Moresco A, Munson L, Gardner IA. Naturally occurring and melengestrol acetate-associated reproductive tract lesions in zoo canids. Vet Pathol. 2009;46:1117–28.

    Article  CAS  PubMed  Google Scholar 

  • Moresco A, Dadone L, Arble J, Klaphake E, Agnew DW. Location and removal of deslorelin acetate implants in female African lions (Panthera leo). J Zoo Wildl Med. 2014;45:397–401.

    Article  PubMed  Google Scholar 

  • Munson L, Bauman JE, Asa CS, Jochle W, Trigg TE. Efficacy of the GnRH analogue deslorelin for suppression of oestrus cycle in cats. J Reprod Fertil Suppl. 2001;57:269–73.

    CAS  PubMed  Google Scholar 

  • Munson L, Chassy LM, Asa C. Efficacy, safety, and reversibility of bisdiamine as a male contraceptive in cats. Theriogenology. 2004;62:81–92.

    Article  CAS  PubMed  Google Scholar 

  • Munson L, Moresco A, Calle PP. Adverse effects of contraceptives. In: Asa CS, Porton IJ, editors. Wildlife contraception: issues, methods, and application. Baltimore: Johns Hopkins University Press; 2005. p. 66–82.

    Google Scholar 

  • Nash PB, James DK, Hui LT, Miller LA. Fertility control of California ground squirrels using GnRH immunocontraception. In: Timm RM, Gorenzel WP, editors. 21st vertebrate pest conference. Davis: University of California-Davis; 2004. p. 274–8.

    Google Scholar 

  • Nave CD, Coulson G, Poiani A, Shaw G, Renfree MB. Fertility control in the eastern grey kangaroo using levonorgestrel implants. J Wildl Manag. 2002;66:470–7.

    Article  Google Scholar 

  • Nettles VF. Potential consequences and problems with wildlife contraceptives. Reprod Fertil Dev. 1997;9:137–44.

    Article  CAS  PubMed  Google Scholar 

  • Nolan MB, Bertschinger HJ, Roth R, Crampton M, Martins IS, Fosgate GT, Stout TA, Schulman ML. Ovarian function following immunocontraceptive vaccination of mares using native porcine and recombinant zona pellucida vaccines formulated with a non-Freund’s adjuvant and anti-GnRH vaccines. Theriogenology. 2018;120:111–6.

    Article  CAS  PubMed  Google Scholar 

  • Nolan MB, Schulman ML, Botha AE, Human A-M, Roth R, Crampton MC, Bertschinger HJ. Serum antibody immunoreactivity and safety of native porcine and recombinant zona pellucida vaccines formulated with a non-Freund’s adjuvant in horses. Vaccine. 2019;37:1299–306.

    Article  CAS  PubMed  Google Scholar 

  • Nuñez CMV, Adelman JS, Rubenstein DI. Immunocontraception in wild horses (Equus caballus) extends reproductive cycling beyond the normal breeding season. PLoS One. 2010;5:e13635.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Okeson DM, Higbie CT, Mylniczenko ND, Haynes A, Bennett S, Klocke E, Carpenter JW. Management of endometriosis in two captive mandrills (Mandrillus sphinx). J Zoo Wildl Med. 2016;47:614–7.

    Article  PubMed  Google Scholar 

  • Oliveira ECS, Moura MR, Silva VA, Peixoto CA, Saraiva KLA, de Sá MJC, Douglas RH, de Pinho Marques A. Intratesticular injection of a zinc-based solution as a contraceptive for dogs. Theriogenology. 2007;68(2):137–45.

    Article  CAS  PubMed  Google Scholar 

  • Oliver M, Piertney S, Zalewski A, Melero Y, Lambin X. The compensatory potential of increased immigration following intensive American mink population control is diluted by male-biased dispersal. Biol Invasions. 2016;18:3047–61.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oogjes G. Ethical aspects and dilemmas of fertility control of unwanted wildlife: an animal welfarist’s perspective. Reprod Fertil Dev. 1997;9:163–8.

    Article  CAS  PubMed  Google Scholar 

  • Orford H, Perrin M, Berry H. Contraception, reproduction and demography of free-ranging Etosha lions (Panthera leo). J Zool. 1988;216:717–33.

    Article  Google Scholar 

  • Pai M, Bruner R, Schlafer DH, Yarrow GK, Yoder CA, Miller LA. Immunocontraception in eastern gray squirrels (Sciurus carolinensis): morphologic changes in reproductive organs. J Zoo Wildl Med. 2011;42:718–22.

    Article  PubMed  Google Scholar 

  • Patton ML, Jochle W, Penfold LM. Contraception in ungulates. In: Asa CS, Porton IJ, editors. Wildlife contraception: issues, methods and application. Baltimore: Johns Hopkins University Press; 2005. p. 149–67.

    Google Scholar 

  • Patton ML, Bashaw MJ, del Castillo SM, Jochle W, Lamberski N, Rieches R, Bercovitch FB. Long-term suppression of fertility in female giraffe using the GnRH agonist deslorelin as a long-acting implant. Theriogenology. 2006;66:431–8.

    Article  CAS  PubMed  Google Scholar 

  • Patton ML, Jochle W, Penfold LM. Review of contraception in ungulate species. Zoo Biol. 2007;26:311–26.

    Article  CAS  PubMed  Google Scholar 

  • Penfold LM, Powell D, Traylor-Holzer K, Asa CS. “Use it or lose it”: characterization, implications, and mitigation of female infertility in captive wildlife. Zoo Biol. 2014;33(1):20–8.

    Article  PubMed  Google Scholar 

  • Pepin KM, Davis AJ, Cunningham FL, VerCauteren KC, Eckery DC. Potential effects of incorporating fertility control into typical culling regimes in wild pig populations. PLoS One. 2017;12:e0183441.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Perry KR, Arjo WM, Bynum KS, Miller LA. GnRH single-injection immunocontraception of black-tailed deer. In: Timm RM, O’Brien JM, editors. Proc 22nd vertebrate pest conference. Davis: University of California-Davis; 2006. p. 72–7.

    Google Scholar 

  • Petritz OA, Guzman DS-M, Paul-Murphy J, Fecteau K, Mete A, Kass PH, Hawkins MG. Evaluation of the efficacy and safety of single administration of 4.7-mg deslorelin acetate implants on egg production and plasma sex hormones in Japanese quail (Coturnix coturnix japonica). Am J Vet Res. 2013;74:316–23.

    Article  CAS  PubMed  Google Scholar 

  • Phraluk O, Wajjwalku W, Siriaroonrat B, Booddee O, Thongtip N. Effects of immunization against gonadotropin releasing hormone on reproductive functions in male rusa deer (Rusa timorensis). Thai J Vet Med. 2015;45:1.

    Google Scholar 

  • Plotka ED, Seal US. Fertility control in female white-tailed deer. J Wildl Dis. 1989;25:643–6.

    Article  CAS  PubMed  Google Scholar 

  • Pope LC, Butlin RK, Wilson GJ, Woodroffe R, Erven K, Conyers CM, Franklin T, Delahay RJ, Cheeseman CL, Burke T. Genetic evidence that culling increases badger movement: implications for the spread of bovine tuberculosis. Mol Ecol. 2007;16:4919–29.

    Article  PubMed  Google Scholar 

  • Powers JG, Baker DL, Davis TL, Conner MM, Lothridge AH, Nett TM. Effects of gonadotropin-releasing hormone immunization on reproductive function and behavior in captive female Rocky Mountain elk (Cervus elaphus nelsoni). Biol Reprod. 2011;85:1152–60.

    Article  CAS  PubMed  Google Scholar 

  • Pozor MA, Macpherson ML, McDonnell SM, Nollin M, Roser JF, Love C, Runyon S, Thomas BF, Troedsson MH. Indenopyride derivative RTI-4587-073(l): a candidate for male contraception in stallions. Theriogenology. 2013;80(9):1006–16.

    Article  CAS  PubMed  Google Scholar 

  • Prohaczik A, Kulcsar M, Trigg T, Huszenicza G. Treatments suppressing ovarian activity in ferrets (Mustela putorius furo). Reprod Domest Anim. 2003;38:331.

    Google Scholar 

  • Raines JA, Fried JJ. Use of deslorelin acetate implants to control aggression in a multi-male group of rock hyrax (Procavia capensis). Zoo Biol. 2016;35:201–4.

    Article  CAS  PubMed  Google Scholar 

  • Ramsey D. Effects of fertility control on behavior and disease transmission in brushtail possums. J Wildl Manag. 2007;71:109–16.

    Article  Google Scholar 

  • Raphael BL, Kalk P, Thomas P, Calle PP, Doherty JG, Cook RA. Use of melengestrol acetate in feed for contraception in herds of captive ungulates. Zoo Biol. 2003;22:455–63.

    Article  CAS  Google Scholar 

  • Reiter DK, Brunson MW, Schmidt RH. Public attitudes toward wildlife damage management and policy. Wildl Soc Bull. 1999;27:746–58.

    Google Scholar 

  • Remfry J. Control of feral cat populations by long term administration of megestrol acetate. Vet Rec. 1978;28:403–4.

    Article  Google Scholar 

  • Roelle JE, Ransom J. Injection-site reactions in wild horses (Equus caballus) receiving an immunocontraceptive vaccine. US Geological Survey Scientific Investigations Report: 2009-5038; 2009. 15 pp.

    Google Scholar 

  • Romatowski J. Use of megestrol acetate in cats. J Am Vet Med Assoc. 1989;194:700–2.

    CAS  PubMed  Google Scholar 

  • Roughton RD. Effects of oral melengestrol acetate on reproduction in captive white-tailed deer. J Wildl Manag. 1979;43:428–36.

    Article  CAS  Google Scholar 

  • Rowland MN. Use of a deslorelin implant to control aggression in a male bearded dragon (Pogona vitticeps). Vet Rec. 2011;169:127.

    Article  CAS  PubMed  Google Scholar 

  • Rutberg A, Grams K, Turner JW Jr, Hopkins H. Contraceptive efficacy of priming and boosting doses of controlled-release PZP in wild horses. Wildl Res. 2017;44:174–81.

    Article  CAS  Google Scholar 

  • Sacco AG, Subramanian MG, Yurewicz EC, DeMayo FJ, Dukelow WR. Heteroimmunization of squirrel monkeys (Saimiri sciureus) with a purified porcine zona antigen (PPZA): immune response and biologic activity of antiserum. Fertil Steril. 1983;39:350–8.

    Article  CAS  PubMed  Google Scholar 

  • Sacks BN, Jaeger MM, Jennifer CCN, McCullough DR. Territoriality and breeding status of coyotes relative to sheep predation. J Wildl Manag. 1999;63:593–605.

    Article  Google Scholar 

  • Schulman ML, Botha AE, Muenscher SB, Annandale CH, Guthrie AJ, Bertschinger HJ. Reversibility of the effects of GnRH-vaccination used to suppress reproductive function in mares. Equine Vet J. 2013;45:111–3.

    Article  CAS  PubMed  Google Scholar 

  • Selman PJ, Mol JA, Rutteman GR, Rijnberk A. Progestin treatment in the dog. I. Effects on growth hormone, insulin-like growth factor I and glucose homeostasis. Eur J Endocr. 1994;131:413–21.

    Article  CAS  Google Scholar 

  • Selman PJ, Mol JA, Rutteman GR, van Garderen E, van den Ingh TS, Rijnberk A. Effects of progestin administration on the hypothalamic-pituitary-adrenal axis and glucose homeostasis in dogs. J Reprod Fertil Suppl. 1997;51:345–54.

    CAS  PubMed  Google Scholar 

  • Shideler SE, Stoops MA, Gee NA, Howell JA, Lasley BL. Use of porcine zona pellucida (PZP) vaccine as a contraceptive agent in free-ranging tule elk (Cervus elaphus nannodes). J Reprod Fertil Suppl. 2002;60:169–76.

    CAS  Google Scholar 

  • Shuster SM, Pyzyna B, Mayer LP, Dyer CA. The opportunity for sexual selection and the evolution of non-responsiveness to pesticides, sterility inducers and contraceptives. Heliyon. 2018;4:e00943.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sitruk-Ware R. Reprint of pharmacological profile of progestins. Maturitas. 2008;61:151–7.

    Article  PubMed  Google Scholar 

  • Skinner DC, Albertson AJ, Navratil A, Smith A, Mignot M, Talbott H, Scanlan-Blake N. Effects of gonadotropin-releasing hormone outside the hypothalamis-pituitary-reproductive axis. J Neuroendocrinol. 2009;21:282–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sloan JM, Oliver IM. Progestogen-induced diabetes in the dog. Diabetes. 1975;24:337–44.

    Article  CAS  PubMed  Google Scholar 

  • Snape MA. Reproductive and behavioural effects of a GnRH-targeted immunocontraceptive vaccine in macropodids. Canberra: Australian National University; 2012. p. 167.

    Google Scholar 

  • Spence CE, Kenyon JE, Smith DR, Hayes RD, Baer AM. Surgical sterilization of free-ranging wolves. Can Vet J. 1999;40:118–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stringer EM, De Voe RS, Loomis MR. Suspected anaphylaxis to leuprolide acetate depot in two elf owls (Micrathene whitneyi). J Zoo Wildl Med. 2011;42:166–8.

    Article  PubMed  Google Scholar 

  • Taylor LH, Wallace RM, Balaram D, Lindenmayer JM, Eckery DC, Mutonono-Watkiss B, Parravani E, Nel LH. The role of dog population management in rabies elimination—a review of current approaches and future opportunities. Front Vet Sci. 2017;4 https://doi.org/10.3389/fvets.2017.00109.

  • Tribe A, Hanger J, McDonald I, Loader J, Nottidge B, McKee J, Phillips C. A reproductive management program for an urban population of eastern grey kangaroos (Macropus giganteus). Animals. 2014;4:562–82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Turner JW Jr, Liu IKM, Kirkpatrick JF. Remotely delivered immuno-contraception in free-roaming feral burros (Equus asinus). J Reprod Fertil. 1996;107:31–5.

    Article  CAS  PubMed  Google Scholar 

  • Turner JW, Liu IKM, Flanagan DR, Rutberg AT, Kirkpatrick JF. Immunocontraception in wild horses: one inoculation provides two years of infertility. J Wildl Manag. 2007;71:662–7.

    Article  Google Scholar 

  • Twigg L, Kent Williams C. Fertility control of overabundant species; can it work for feral rabbits? Ecol Lett. 1999;2:281–5.

    Article  PubMed  Google Scholar 

  • Vargas-Pino F, Gutierrez-Cedillo V, Vanales-Vargas EJ, Gress-Ortega LR, Miller LA, Rupprecht CE, et al. Concomitant administration of GonaCon™ and rabies vaccine in female dogs (Canis familiaris) in Mexico. Vaccine. 2013;31:4442–7.

    Article  CAS  PubMed  Google Scholar 

  • Wallace PY, Asa CS, Agnew M, Cheyne SM. A review of population control methods in captive-housed primates. Anim Welf. 2016;25:7–20.

    Article  Google Scholar 

  • Wheaton CJ, Savage A, Shukla A, Neiffer DL, Qu W, Sun Y, Lasley B. The use of long acting subcutaneous levonorgestrel (LNG) gel depot as an effective contraceptive option for cotton-top tamarins (Saguinus oedipus). Zoo Biol. 2011;30:498–522.

    Article  CAS  PubMed  Google Scholar 

  • Wilkins L. Masculinization of female fetus due to use of orally given progestins. J Am Vet Med Assoc. 1960;172:1028–32.

    Article  CAS  Google Scholar 

  • Willers N, Martin G, Matson P, Mawson P, Morris K, Bencini R. Finding the balance: fertility control for the management of fragmented populations of a threatened rock-wallaby species. Animals. 2015;5:0414.

    Article  Google Scholar 

  • Wilson ME, Coulson G, Shaw G, Renfree MB. Deslorelin implants in free-ranging female eastern grey kangaroos (Macropus giganteus): mechanism of action and contraceptive efficacy. Wildl Res. 2013;40:403–12.

    Article  CAS  Google Scholar 

  • Woodroffe R, Frank LG. Lethal control of African lions (Panthera leo): local and regional population impacts. Anim Conserv. 2005;8:91–8.

    Article  Google Scholar 

  • Wright PJ, Verstegen JP, Onclin K, Jochle W, Armour AF, Martin GB, Trigg TE. Suppression of the oestrous responses of bitches to the GnRH analogue deslorelin by progestin. J Reprod Fertil Suppl. 2001;57:263–8.

    CAS  PubMed  Google Scholar 

  • Yoder CA, Miller LA. Effect of GonaCon™ vaccine on black-tailed prairie dogs: immune response and health effects. Vaccine. 2010;29:233–9.

    Article  CAS  PubMed  Google Scholar 

  • Yoder C, Bynum K, Miller L. Development of Diazacon as an avian contraceptive. In: Wildlife damage management. Lincoln: University of Nebraska; 2005. p. 190–201.

    Google Scholar 

  • Yoder CA, Mayle BA, Furcolow CA, Cowan DP, Fagerstone KA. Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry. Integr Zool. 2011;6:409–19.

    Article  PubMed  Google Scholar 

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Asa, C., Moresco, A. (2019). Fertility Control in Wildlife: Review of Current Status, Including Novel and Future Technologies. In: Comizzoli, P., Brown, J., Holt, W. (eds) Reproductive Sciences in Animal Conservation. Advances in Experimental Medicine and Biology, vol 1200. Springer, Cham. https://doi.org/10.1007/978-3-030-23633-5_17

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