Determination of Skeletal Tumor Burden on 18F-Fluoride PET/CT
Since first proposed in 1999 by Larson et al. , the use of volumetric quantification techniques on PET/CT exams has become increasingly popular to evaluate tumor burden, especially with 18F-FDG. The volumetric quantification of tumor burden has been shown to correlate with prognosis and is also an objective means to evaluate response to treatment in a variety of cancers .
Skeletal tumor burden (FTV and TFL) is obtained by volumetric quantification of 18F-fluoride PET/CT studies and could be used as an imaging biomarker for evaluation of prognosis and response to therapy for many cancers. FTV and TFL can be measured manually or semiautomatically. We will demonstrate the step-by-step quantification process both manually and semi-automatically.
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