Clinical Presentation of Brain Metastases

  • Annette Compter
  • Dieta BrandsmaEmail author


Brain metastases can result in a large variety of focal and nonfocal neurological symptoms. The clinical presentation of brain metastases is affected by the location, size and growth rate of the tumour. Any new neurological symptom or change in behaviour or cognition in a patient with cancer warrants further investigations for brain metastases. Focal neurological symptoms, like hemiparesis and dysphasia, can be caused by a direct effect of the brain metastasis or the surrounding oedema on the brain tissue or other neural structures. Most of these neurological symptoms occur within days to weeks, although an intratumoural haemorrhage can result in an acute onset of symptoms. Epileptic seizures occur in 10–20% of patients with brain metastases.


Brain metastases Neurological symptoms Hydrocephalus Brain herniation Epilepsy 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Neuro-oncologyNetherlands Cancer Institute—Antoni van LeeuwenhoekAmsterdamThe Netherlands

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