Neurological Complications of Immune-Based Therapies

  • Ugonma N. Chukwueke
  • Eudocia Q. Lee
  • Patrick Y. WenEmail author


As collective knowledge of the immunological underpinnings of disease has risen, this has spurred the development and use of new, immune-based cancer therapies. While harnessing the immune system to target solid and hematologic malignancies has led to a shift in treatment paradigms, immune-related adverse effects are becoming apparent and recognized. Similar to cytotoxic and targeted therapies, neurotoxicity secondary to immunotherapy and immune-based therapies are a rare but important phenomenon given risk of misdiagnosis and treatment delays. The use of immune-based therapies is expected to increase, particularly as novel combinations and newer approaches emerge; thus, the need for early diagnosis and timely treatment to prevent neurologic morbidity is critical.


Immune checkpoint inhibition Immune-related adverse effects CAR T-cell therapy BiTE antibody 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ugonma N. Chukwueke
    • 1
    • 2
  • Eudocia Q. Lee
    • 1
    • 2
  • Patrick Y. Wen
    • 1
    • 2
    Email author
  1. 1.Department of Medical Oncology, Center for Neuro-Oncology, Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  2. 2.Department of Neurology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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