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Other Fungal Arthritis

  • Luis Alberto Ramírez Gómez
  • Alejandro Vélez Hoyos
Chapter

Abstract

In this chapter we review the etiological, epidemiological, and clinical aspects as well as diagnostic aids and treatment of joint infection and osteomyelitis by fungi such as aspergillosis, sporotrichosis, cryptococcosis, paracoccidioidomycosis, and mucormycosis.

Keywords

Osteomyelitis Arthritis by fungi Aspergillosis Cryptococcosis Sporotrichosis Paracoccidioidomycosis Mucormycosis 

References

  1. 1.
    Bariteau JT, Waryasz GR, McDonnell M, Fischer SA, Hayda RA, et al. Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg. 2014;22:390–401.CrossRefGoogle Scholar
  2. 2.
    Henry MW, Miller AO, Walsh TJ, Brause BD. Fungal musculoskeletal infections. Infect Dis Clin N Am. 2017;31:353–68.CrossRefGoogle Scholar
  3. 3.
    Schwarz J. What’s new mycotic bone and joint diseases? Path Res Pract. 1984;178:617–34.CrossRefGoogle Scholar
  4. 4.
    Wang LR, Barber CE, Johnson AS, Barnabe C. Invasive fungal disease in systemic lupus erythematous: a systematic review of disease characteristics, risk factor and prognosis. Sem Arthritis Rheum. 2014;44(3):325–30.  https://doi.org/10.1016/j.semarthrit.2014.06.0010049-0172.CrossRefGoogle Scholar
  5. 5.
    González LA, Vásquez G, Restrepo JP, Velásquez M, Ramírez LA. Cryptococcosis in systemic lupus erythematosus: a series of six cases. Lupus. 2010;19:639–45.CrossRefGoogle Scholar
  6. 6.
    Ramírez LA, Velásquez JF, Granda P, Builes CA, Jaimes F. Asociación de actividad lúpica y el riesgo de infección nosocomial en pacientes de un hospital universitario en Medellín: estudio prospectivo 2001-2004. Rev Colomb Reumatol. 2007;14:177–86.Google Scholar
  7. 7.
    Koehler P, Tacke D, Cornely OA. Aspergillosis of bones and joints- a review from 2002 until today. Mycoses. 2014;57:323–35.CrossRefGoogle Scholar
  8. 8.
    Gamaletsou MN, Rammaert B, Bueno MA, Sipsas NV, Moriyama B, et al. Aspergillus arthritis: analysis of clinical manifestations, diagnosis, and treatment of 31 reported cases. Med Mycol. 2017;55(3):246–54.  https://doi.org/10.1093/mmy/myw077.CrossRefPubMedGoogle Scholar
  9. 9.
    Gunsilius E, Lass-Flörl C, Mur E, Gabl C, Gastl G, et al. Aspergillus osteoarthritis in acute lymphoblastic leukemia. Ann Hematol. 1999;78:529–30.CrossRefGoogle Scholar
  10. 10.
    Kwong CA, Puloski SKT, Hildebrand KA. Fungal periprosthetic joint infection following total elbow arthroplasty: a case report and review of the literature. J Med Case Rep. 2017;11:20.  https://doi.org/10.1186/s13256-016-1176-0.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Sun L, Zhang L, Wang K, Wang W, Tian M. Fungal osteomyelitis after arthroscopy anterior cruciate ligament reconstruction: a case report with review of the literature. Knee. 2012;19:728–31.CrossRefGoogle Scholar
  12. 12.
    Yoon PW, Song JH, Yoon KS, Chang JS, Kim HJ, et al. Aspergillus septic arthritis of the hip in an immunocompetent middle-aged female with undiagnosed recurrent pulmonary aspergillosis. Hip Pelvis. 2015;27:196–200.CrossRefGoogle Scholar
  13. 13.
    Cortet B, Depres X, Triki R, Savage C, Flipo RM, et al. Aspergillus spondylodiscitis. Apropos of 5 cases. Rev Rhum. 1993;60:37–44.Google Scholar
  14. 14.
    Kumar M, Thilak J, Zahoor A, Jyothi A. Septic arthritis due to tubercular and aspergillus co-infection. Indian J Orthop. 2016;50:327–30.CrossRefGoogle Scholar
  15. 15.
    Patterson TF. Aspergillus species. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennet’s Infectious disease essentials. 1st ed. Philadelphia: Elsevier; 2017. p. 381–2.Google Scholar
  16. 16.
    Perfect JR. Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii). In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennet’s infectious disease essentials. 1st ed. Philadelphia: Elsevier; 2017. p. 390–2.Google Scholar
  17. 17.
    Liao T-L, Chen Y-M, Chen D-Y. Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications. Clin Microbiol Infect. 2016;22:815.e1.  https://doi.org/10.1016/J.cmi.2016.05.030.CrossRefGoogle Scholar
  18. 18.
    Garau M, del Palacio A. Artritis por Cryptococcus neoformans en receptor de trasplante renal. Rev Iberoam Micol. 2002;19:186–9.PubMedGoogle Scholar
  19. 19.
    Geller DS, Pope JB, Thornhill BA, Dorfman HD. Cryptococcal pyarthrosis and sarcoidosis. Skelet Radiol. 2009;38:721–7.CrossRefGoogle Scholar
  20. 20.
    Kozic H, Riggs K, Ringpfeil F, Lee JB. Letter. Disseminated Cryptococcus neoformans after treatment with infliximab for rheumatoid arthritis. J Am Acad Dermatol. https://doi.org/10.1016/J.Jaad.2006.12.012.CrossRefGoogle Scholar
  21. 21.
    Bruno KM, Farhoomand L, Libman BS, Pappas CN, Landry FJ. Cryptococcal arthritis, tendinitis, tenosynovitis, and carpal tunnel syndrome: report of a case and review of the literature. Arthritis Care Res. 2002;47:104–8.CrossRefGoogle Scholar
  22. 22.
    Moosbruger EA, Adams BB, Kralovic SM. Cutaneous cryptococcosis in a patient on corticosteroid therapy for rheumatoid arthritis. Inter J Dermatol. 2008;47:630–2.CrossRefGoogle Scholar
  23. 23.
    Bunning RD, Barth WF. Cryptococcal arthritis and cellulitis. Ann Rheum Dis. 1984;43:508–10.CrossRefGoogle Scholar
  24. 24.
    Jang DW, Jeong I, Kim SJ, Kim SW, Park SY, et al. Pulmonary cryptococcosis that mimicked rheumatoid nodule in rheumatoid arthritis lesion. Tuberc Respir Dis (Seoul). 2014;77(6):266–70.  https://doi.org/10.4046/trd.2014.77.6.266.CrossRefGoogle Scholar
  25. 25.
    Gil G, Foster C, Neira O, Palma S, Basualdo J, et al. Artritis por Cryptococcus neoformans en un adulto mayor: presentación de un caso y revisión. Rev Chil Infect. 2006;23:330–5.Google Scholar
  26. 26.
    Stead KJ, Klugman KP, Painter ML, Koornhof HJ. Septic arthritis due to Cryptococcus neoformans. J Infect. 1988;17:139–45.CrossRefGoogle Scholar
  27. 27.
    Lesperance M, Baumgartner D, Kauffman CA. Polyarticular arthritis due to Sporothrix schenckii. Mycoses. 1988;31:599–603.CrossRefGoogle Scholar
  28. 28.
    Solorzano S, Ramirez R, Cabada MM, Montoya M, Cazorla E. Esporotricosis cutánea diseminada con compromiso articular en una mujer con diabetes tipo 2. Rev Per Med Exp Salud Pública. 2015;32:187–90.CrossRefGoogle Scholar
  29. 29.
    Campos-Macias P, Arenas R, Vega-Memije ME, Kawasaki M. Sporothrix schenckii type 3D (mtDNA-RFLP): report of an osteoarticular case. J Dermatol. 2006;33:295–9.CrossRefGoogle Scholar
  30. 30.
    Barbaryan A, El Atrouni W, Bailuc S, Jones MW, Bhakta M, et al. Isolated Sporothrix schenckii monoarthritis. Case Rep Infect Dis. 2018;2018:1.  https://doi.org/10.1155/2018/9037657.CrossRefGoogle Scholar
  31. 31.
    Orofino-Costa R, Bóia MN, Magalhäes GAP, Damasco PS, Bernardes-Engemann AR, et al. Arthritis as a hypersensitivity reaction in a case of sporotrichosis transmitted by a sick cat: clinical and serological follow up of 13 months. Mycoses. 2009;53:81–3.CrossRefGoogle Scholar
  32. 32.
    Appenzeller S, Amaral TN, Amstalden EMI, Bertolo MB, et al. Sporothrix schenckii infection presented as monoarthritis: report of two cases and review of the literature. Clin Rheumatol. 2006;25:926–8.CrossRefGoogle Scholar
  33. 33.
    Cuéllar ML, Silveira LH, Espinoza LR. Fungal arthritis. Ann Rheum Dis. 1992;51:690–7.CrossRefGoogle Scholar
  34. 34.
    Carvalho Aguinaga F, Moritz Trope B, Conceicao Fernandes N, Celser Engel D, Ramos-e-Silva M. Sporotrichosis with bone involvement: an alert to an occupational disease. Case Rep Dermatol. 2014;6:114–8.CrossRefGoogle Scholar
  35. 35.
    Purvis RS, Diven DG, Drechsel RD, Calhoun JH, Tyring SK. Sporotrichosis presenting as arthritis and subcutaneous nodules. J Am Acad Dermatol. 1993;28:879–84.CrossRefGoogle Scholar
  36. 36.
    Downs NJ, Hinthorn DR, Mhatre VR, Liu C. Intra-articular amphotericin B treatment of Sporothrix schenckii arthritis. Arch Intern Med. 1989;149:954–5.CrossRefGoogle Scholar
  37. 37.
    Goddhan A, Ramdial PK, Morar N, Moodley SD, Aboobaker J. Disseminated cutaneous sporotrichosis: a marker of osteoarticular sporotrichosis masquerading as gout. Inter J Dermatol. 2001;40:717–9.CrossRefGoogle Scholar
  38. 38.
    Chowdhary G, Weinstein A, Klein R, Mascarenhas BR. Sporotrichal arthritis. Ann Rheum Dis. 1991;50:112–4.CrossRefGoogle Scholar
  39. 39.
    Crout JE, Brewer NS, Tompkins RB. Sporotrichosis arthritis. Clinical features in seven patients. Ann Int Med. 1977;86:294–7.CrossRefGoogle Scholar
  40. 40.
    Shimizu T, Akita S, Harada Y, Oguro E, Okita Y, et al. Sporotrichal tenosynovitis diagnosed helpfully by musculoskeletal ultrasonography. Int Med. 2017;56:1243–6.CrossRefGoogle Scholar
  41. 41.
    Orzechowski Xavier M, Riffel Bittencourt L, Moss da Silva C, Stone Vieira R, Pacheco Pereira HC. Atypical presentation of sporotrichosis: report of three cases. Rev Soc Bras Med Trop. 2013;46:116–8.CrossRefGoogle Scholar
  42. 42.
    Orofino Costa R, Celso de Mesquita K, Damasco PS, Bernardes-Engemann AR, Dias CMP, Silva IC, et al. Infectious arthritis as the single manifestation of sporotrichosis: serology from serum and synovial fluid samples as an aid to diagnosis. Rev Iberoam Micol. 2008;25:54–6.CrossRefGoogle Scholar
  43. 43.
    Schwartz DA. Sporothrix tenosynovitis- differential diagnosis of granulomatous inflammatory disease of the joints. J Rheumatol. 1989;18:550–3.Google Scholar
  44. 44.
    Halverson PB, Lahiri S, Wojno WC, Sulaiman AR. Sporotrichal arthritis presenting as granulomatous Myositis. Arthritis Rheum. 1985;28:1425–9.CrossRefGoogle Scholar
  45. 45.
    Yamaguchi T, Ito S, Takano Y, Umeda N, Goto M, et al. A case disseminated sporotrichosis treated with prednisolone, immunosuppressants, and tocilizumab under diagnosis of rheumatoid arthritis. Int Med. 2012;51:2035–9.CrossRefGoogle Scholar
  46. 46.
    Gottlieb GS, Lesser CF, Holmes KK, Wald A. Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-α antagonists. CID. 2003;37:838–40.CrossRefGoogle Scholar
  47. 47.
    Restrepo A, Tobón AM, Cano LE. Paracoccidioidomycosis. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett’s infectious disease essentials. 1st ed. Philadelphia: Elsevier; 2017. p. 402–3.Google Scholar
  48. 48.
    Torrado E, Castañeda E, de la Hoz F, Restrepo A. Paracoccidioidomicosis: definición de las áreas endémicas de Colombia. Biomedica. 2000;20:327–34.CrossRefGoogle Scholar
  49. 49.
    Bellissimo-Rodrigues F, Artioli Machado A, Martinez R. Paracoccidioidomycosis epidemiological features of a 1,000-cases series from a hyperendemic área on the southeast of Brazil. Am J Trop Med Hyg. 2011;85:544–50.CrossRefGoogle Scholar
  50. 50.
    Moretti Monsignore L, Martinez R, Novelino Simao M, Reis Teixeira S, Elias J Jr, et al. Radiologic findings of osteoarticular infection in paracoccidioidomycosis. Skelet Radiol. 2012;41:203–8.CrossRefGoogle Scholar
  51. 51.
    Moira T, Rosanova MT, Bes D, Lisdero ML, Iglesias V, et al. Paracoccidioidomicosis en Pediatria. Rev Iberoam Micol. 2014;31:141–4.CrossRefGoogle Scholar
  52. 52.
    Bonilla-Abadía F, Vélez JD, Zárate-Correa LC, Carrascal E, Guarín N, et al. Overinfection by Paracoccidioides brasiliensis in gouty crystal arthritis. Case Report Med. 2012;2012:1.  https://doi.org/10.1155/2012/128103.CrossRefGoogle Scholar
  53. 53.
    Mendonca JA, Peron Filho F, Bossolan Schincariol N, Vierhout CV, Provenza JR. Musculoskeletal ultrasound findings in paracoccidioidomycosis. Rev Bras Reumatol. 2016;56:75–8.CrossRefGoogle Scholar
  54. 54.
    Savarese LG, Monsignore LM, de Andrade Hernandes M, Martinez R, Nogueira-Barbosa MH. Magnetic resonance imaging findings of paracoccidioidomycosis in the musculoskeletal system. Tropical Med Int Health. 2015;20:1346–54.CrossRefGoogle Scholar
  55. 55.
    Cardona Gómez MC, Martinez lópez CI, Ramírez Barrera JD. Paracoccidiodomicosis y artritis reumatoide. Una rara asociación. Med Lab. 2010;16:243–52.Google Scholar
  56. 56.
    de Camargo ZP. Serology of paracoccidioidomycosis. Mycopathologia. 2008;165:289–302.CrossRefGoogle Scholar
  57. 57.
    Almeida Araujo S, Magalhaes Espindola B, Pietra Pedroso ER. Cutaneous disseminated paracoccidiodomycosis. Am J Trop Med Hyg. 2012;86:1.  https://doi.org/10.4269/ajtmh.2012.11-0347.CrossRefGoogle Scholar
  58. 58.
    Kohelert P, Tacke D, Cornely OA. Bone and joint infections by Mucorales, Scedosporium, Fusarium and even rarer fungi. Crit Rev Microbiol. 2014;42:158.  https://doi.org/10.3109/1040841X.2014.910749.CrossRefGoogle Scholar
  59. 59.
    Odessey E, Cohn A, Beaman K, Schechter L. Invasive mucormycosis of the maxillary sinus: extensive destruction with an indolent presentation. Surg Infect. 2008;9:91–8.CrossRefGoogle Scholar
  60. 60.
    Taj-Aldeen SJ, Gamaletsou MN, Rommaert B, Sipsas NV, Zeller V, et al. Bone and joint infections caused by mucormycetes: A Challenging osteoarticular mycosis of the twenty-first century. Med Mycol. 2017;55(7):691–704.  https://doi.org/10.1093/mmy/myw136.CrossRefPubMedPubMedCentralGoogle Scholar
  61. 61.
    Taj-Aldeen SJ, Rammaert B, Gamaletsou M, Sipsas NV, Zeller V, et al. Osteoarticular infections caused by non-Aspergillus filamentous fungi in adult and pediatric patients. A systematic review. Medicine. 2015;94:1–13.CrossRefGoogle Scholar
  62. 62.
    Requena L, Sitthinamsuwan P, Santoja C, Fernández-Figueras MT, Rodriguez-Peralto JL, et al. Cutaneous and mucosal mucormycosis mimicking pancreatic panniculitis and gouty panniculitis. J Am Acad Dermatol. 2012;66(6):975–84.  https://doi.org/10.1016/j-jaad.2011.06.024.CrossRefPubMedGoogle Scholar
  63. 63.
    Camargo JF, Yakoub D, Cho-Vega JH. Successful treatment cutaneous mucormycosis complicating anti-TNF therapy with a combination of surgical debridement and oral posaconazole. Mycopathologia. 2015;180:187.  https://doi.org/10.1007/s11046-015-9914-1.CrossRefPubMedGoogle Scholar
  64. 64.
    Gadadhar H, Hawkins S, Huffsttutter JE, Panda M. Cutaneous mucormycosis complicating methotrexate, prednisone, and infliximab therapy. J Clin Rheumatol. 2007;13:361–2.CrossRefGoogle Scholar
  65. 65.
    Muscolo DL, Carbo L, Aponte-Tinao LA, Ayerza MA, Makino A. Massive bone loss from fungal infection after anterior cruciate ligament arthroscopic reconstruction. Clin Orthop Relat Res. 2009;467:2420–5.CrossRefGoogle Scholar
  66. 66.
    Cornely OA, Petrikkos G. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis. Clin Microbiol Infect. 2014;20. (Suppl. 3:5–26.CrossRefGoogle Scholar
  67. 67.
    Kauffman CA, Bustamante B, Chapman SW, Pappas P. Clinical practical guidelines for the management of sporotrichosis: 2007 update by the infectious diseases society of America. Clin Infect Dis. 2007;45:1255–65.CrossRefGoogle Scholar
  68. 68.
    Perfect JR, Disnukes WE, Dromer F, Goldman D, Graybill JR, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2010;50:291–322.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Luis Alberto Ramírez Gómez
    • 1
  • Alejandro Vélez Hoyos
    • 2
    • 3
  1. 1.Rheumatology DepartmentUniversidad de AntioquiaMedellínColombia
  2. 2.Department of PathologyUniversidad Pontificia BolivarianaMedellínColombia
  3. 3.Hospital Pablo Tobón Uribe and Dinámica IPSMedellínColombia

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