Hepatitis Arthritis: HBV and HCV

  • Rodolfo Perez-Alamino


Viral infections are a well-recognized cause of arthralgia and arthritis. Diagnosis of virally induced arthritis can be difficult to confirm but should be considered in all patients presenting with acute-onset polyarticular symptoms. Hepatitis B and C infections are frequently recognized as causative agents of arthritis. This manifestation could be the only presenting feature of acute HBV and HCV infection and often resembles rheumatoid arthritis, with a symmetrical polyarticular distribution. HCV chronic infection is usually associated with arthralgia, myalgia, cryoglobulinemia vasculitis, sicca syndrome, and a vast array of autoantibodies production. Previous treatment of HCV has been based on interferon, which has been associated with poor efficacy, high rates of side effects, and risk of exacerbation of autoimmune diseases. Actually, the new oral interferon-free regimens offer the opportunity for those patients to be cured with a low risk of side effects and a short treatment duration.


Hepatitis B Hepatitis C Rheumatic manifestations Arthritis Arthralgia Myalgia Cryoglobulinemia Vasculitis Sicca syndrome Interferon Direct antiviral agents Immunosuppressants Rituximab 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rodolfo Perez-Alamino
    • 1
  1. 1.Rheumatology Section, Department of Internal MedicineHospital AvellanedaTucumánArgentina

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