Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon

  • Alexander A. MironovEmail author
  • Ivan D. Dimov
  • Galina V. Beznoussenko
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 67)


The intracellular transport is the most confusing issue in the field of cell biology. The Golgi complex (GC) is the central station along the secretory pathway. It contains Golgi glycosylation enzymes, which are responsible for protein and lipid glycosylation, and in many cells, it is organized into a ribbon. Position and structure of the GC depend on the position and function of the centriole. Here, we analyze published data related to the role of centriole and intracellular transport (ICT) for the formation of Golgi ribbon and specifically stress the importance of the delivery of membranes containing cargo and membrane proteins to the cell centre where centriole/centrosome is localized. Additionally, we re-examined the formation of Golgi ribbon from the point of view of different models of ICT.


Golgi complex Intracellular transport Intra-Golgi transport ER-Golgi transport Golgi ribbon Centriole Coatomer I Coatomer II 


Apo B

Apolipoprotein B


Arf GTPase activating protein


Trafficking protein particle complex subunit BET3


Cis-most cisterna


Compartment (cisterna) maturation progression model




Diffusion model


ER-Golgi carrier


ER-Golgi transport


Endoplasmic reticulum


ER exit site


Golgi complex


Green fluorescent protein


Golgi microtubule-associated protein 210 KDa




Inter-cisternal connections


Intracellular transport


Intra-Golgi transport


Kiss-and-run model


Kinesin family member C3






N-ethylmaleimide-sensitive factor


Plasma membrane


Ras-related in the brain


Secretion-associated RAS superfamily-related gene


Secretory clone


Synaptosomal-associated protein


Soluble NSF attachment receptor


Trans-Golgi network


Trans-most cisterna


Thyroid receptor-interacting protein 11


Very low-density lipoprotein


Vesicular model


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alexander A. Mironov
    • 1
    Email author
  • Ivan D. Dimov
    • 2
  • Galina V. Beznoussenko
    • 1
  1. 1.The FIRC Institute of Molecular OncologyMilanItaly
  2. 2.Department of AnatomySaint Petersburg State Paediatric Medical UniversitySaint PetersburgRussia

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