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Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?

  • Marie Lejong
  • Nathalie Vanmuylder
  • Stéphane LouryanEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 19)

Abstract

Primordial Germ Cells (PGC) are the progenitors of the germ-line and differentiate into spermatozoa or oocytes. They are responsible for the transmission of genetic and epigenetic information from one generation to the other. Since the nineteenth century, PGCs have been investigated using different techniques. Regardless of their mode of specification, inheritance or induction, PGCs arise early in development and migrate by a combination of passive and active movements towards the gonadic ridges. The migration of PGCs is very similar to the path taken by metastasis and germ cells are very often proposed as a model for the study of cell migration. Their pathway of migration is regulated by different signals that interact with Hsp90, an ATP-dependent chaperone associated with numerous tumors and used to grade the malignancy. Furthermore, some of the signals regulating PGCs have been proved to have a role in different cancers. This underlines the idea that PGCs could be an interesting tool to study long-distance cell migration and perhaps cancer.

Keywords

Cancer Embryo Hsp90 Migration Primordial germ cell 

Abbreviations

actr2

Actin related protein 2 homolog

alk2

Activin receptor-like kinase-2

Bmp

Bone morphogenetic proteins

Bmpr

Bone morphogenetic protein receptor

EMT

Epithelial-mesenchymal transition

GR

Gonadal ridge

Hsp

Heat shock protein

MOTC

Microtubule organizer center

PGC

Primordial germ cells

ROCK/RhoA

Rho-associated protein kinase

TGFβ

Transforming growth factor β

Notes

Acknowledgements

The authors thank Mrs. M. Choa-Duterre for histological sections.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marie Lejong
    • 1
  • Nathalie Vanmuylder
    • 1
  • Stéphane Louryan
    • 1
    Email author
  1. 1.Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of MedicineUniversité Libre de BruxellesBrusselsBelgium

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