Heat Shock Protein 90 and Reproduction in Female Animals: Ovary, Oocyte and Early Embryo

  • Yu-Wei Yang
  • Lu Chen
  • Cai-Xia YangEmail author
Part of the Heat Shock Proteins book series (HESP, volume 19)


The mammalian heat shock protein 90 (HSP90) is the most conserved member of heat shock protein family (HSP), participating in the regulation of various cellular and physiological processes, and stress adaptation and oncogenic transformation as well. In addition, in different animal reproduction system, HSP90 plays a vital function in the folliculogenesis, oogenesis and embryo development, and also contributes to the development and progress of female reproductive diseases. This chapter focuses on the general structure, transcriptional regulation (expression and isoforms) and inhibitors of HSP90 family, and their particular roles in animal female reproductive events.


Early embryos Female reproduction HSP90 Oocyte Ovary 



Protein kinase B


Activator protein 1


Adenosine triphosphate/adenosine diphosphate


Cyclin dependent kinase 1


Cyclin dependent kinase 4


Cumulus-oocyte complexes


Proto-oncogene tyrosine-protein kinase Src


C-terminal domain


Day post-coital


Erb-B2 receptor tyrosine kinase 2


Extracellular regulated protein kinases


FMS-Like tyrosine kinase-3






Glucocorticoid receptor


94-kDa glucose-regulated protein


Germinal vesicle


Germinal vesicle breakdown


Hepatocyte nuclear factor 4 alpha


HSP70-HSP90 organizing protein


Heat shock element


Heat shock factor


Heat shock proteins


Heat shock protein 90


Heat shock protein 90 alpha family class A member 1


Heat shock protein 90 alpha family class B member 1


In vitro maturation


Janus kinase-signal transducer and activator of transcription


Mitogen-activated protein kinases


Middle domain


Metaphase II


MOS proto-oncogene, serine/threonine kinase


Maturation-promoting factor


Nuclear factor kappa-light-chain-enhancer of activated B cells


N-terminal domain




Beta-O-linked N-acetylglucosamine transferase


First polar body


Primordial germ cells


Phosphoinositide 3-kinase/phosphatase and tensin homologue/protein kinase B/mammalian target of rapamycin


Proliferator-activated receptor-γ



San A

Sansalvamide A

San A-amide

Sansalvamide A-amide


Signal transducer and activator of transcription 5


Tumor necrosis factor receptor-associated protein 1


VEGF receptor 2


YTH N6-methyladenosine RNA binding protein 2



Our original work cited herein was supported by the National Natural Science Foundation of China (grant number 31472098) and the Start-up grant from Northeast Agricultural University (C.X.Y.).


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.College of Animal ScienceYangtze UniversityJingzhouChina
  2. 2.College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinChina

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