Heat Shock Protein 60 in Skin Diseases

  • Papapit Tuchinda
  • Visith Thongboonkerd
Part of the Heat Shock Proteins book series (HESP, volume 18)


In addition to serving as a stress regulatory/response protein, heat shock protein 60 (Hsp60) also plays important roles in disease mechanism and progression. This chapter summarizes all aspects of the current knowledge on Hsp60 related to various skin diseases, including acne, atopic dermatitis (AD), dermatitis herpetiformis (DH), vasculitis, Behçet’s disease (BD), microscopic polyangiitis (MPA), systemic sclerosis (SSc), dermatomyositis, lichen planus (LP), and psoriasis. The data have shown that not only human Hsp60 but also its homologs in bacteria or microbes (e.g., GroEL) are involved in immune response and inflammatory cascade of these skin diseases. Furthermore, Hsp60 expression is also associated with severity of some diseases. Therefore, Hsp60 can be considered as a potential target for future development of a useful biomarker for diagnostics and prognostics in skin diseases. Moreover, it may also serve as a new therapeutic target for better treatment outcome.


Chaperone Dermatology Hsp60 Immune response Inflammation Skin disorders 



atopic dermatitis


anti-endothelial cell antibodies


anti-neutrophil cytoplasmic antibodies


Behçet’s disease


dermatitis herpetiformis


heat shock protein 60


intercellular adhesion molecule-1






lichen planus


microscopic polyangiitis




peripheral blood mononuclear cells


systemic lupus erythematosus


systemic sclerosis


transforming growth factor-β


toll-like receptors


tumor necrosis factor-α



This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Papapit Tuchinda
    • 1
  • Visith Thongboonkerd
    • 2
  1. 1.Department of Dermatology, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand
  2. 2.Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

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