Advertisement

Heat Shock Protein 60 in Skin Diseases

  • Papapit Tuchinda
  • Visith Thongboonkerd
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 18)

Abstract

In addition to serving as a stress regulatory/response protein, heat shock protein 60 (Hsp60) also plays important roles in disease mechanism and progression. This chapter summarizes all aspects of the current knowledge on Hsp60 related to various skin diseases, including acne, atopic dermatitis (AD), dermatitis herpetiformis (DH), vasculitis, Behçet’s disease (BD), microscopic polyangiitis (MPA), systemic sclerosis (SSc), dermatomyositis, lichen planus (LP), and psoriasis. The data have shown that not only human Hsp60 but also its homologs in bacteria or microbes (e.g., GroEL) are involved in immune response and inflammatory cascade of these skin diseases. Furthermore, Hsp60 expression is also associated with severity of some diseases. Therefore, Hsp60 can be considered as a potential target for future development of a useful biomarker for diagnostics and prognostics in skin diseases. Moreover, it may also serve as a new therapeutic target for better treatment outcome.

Keywords

Chaperone Dermatology Hsp60 Immune response Inflammation Skin disorders 

Abbreviations

AD

atopic dermatitis

AECA

anti-endothelial cell antibodies

ANCA

anti-neutrophil cytoplasmic antibodies

BD

Behçet’s disease

DH

dermatitis herpetiformis

Hsp60

heat shock protein 60

ICAM-1

intercellular adhesion molecule-1

IFN-γ

interferon-γ

IL

interleukin

LP

lichen planus

MPA

microscopic polyangiitis

MPO

myeloperoxidase

PBMC

peripheral blood mononuclear cells

SLE

systemic lupus erythematosus

SSc

systemic sclerosis

TGF-β

transforming growth factor-β

TLR

toll-like receptors

TNF-α

tumor necrosis factor-α

Notes

Acknowledgements

This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).

References

  1. Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M, Eigenmann P, Hamid Q, Kapp A, Leung DY, Lipozencic J et al (2006) Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL consensus report. Allergy 61:969–987PubMedCrossRefPubMedCentralGoogle Scholar
  2. Alard JE, Dueymes M, Youinou P, Jamin C (2008) HSP60 and anti-HSP60 antibodies in vasculitis: they are two of a kind. Clin Rev Allergy Immunol 35:66–71CrossRefGoogle Scholar
  3. Alard JE, Hillion S, Guillevin L, Saraux A, Pers JO, Youinou P, Jamin C (2011) Autoantibodies to endothelial cell surface ATP synthase, the endogenous receptor for hsp60, might play a pathogenic role in vasculatides. PLoS One 6:e14654PubMedPubMedCentralCrossRefGoogle Scholar
  4. Alrashdan MS, Cirillo N, McCullough M (2016) Oral lichen planus: a literature review and update. Arch Dermatol Res 308:539–551PubMedCrossRefPubMedCentralGoogle Scholar
  5. Bayramgurler D, Ozkara SK, Apaydin R, Ercin C, Bilen N (2004) Heat shock proteins 60 and 70 expression of cutaneous lichen planus: comparison with normal skin and psoriasis vulgaris. J Cutan Pathol 31:586–594PubMedCrossRefPubMedCentralGoogle Scholar
  6. Beylot C, Auffret N, Poli F, Claudel JP, Leccia MT, Del Giudice P, Dreno B (2014) Propionibacterium acnes: an update on its role in the pathogenesis of acne. J Eur Acad Dermatol Venereol 28:271–278CrossRefGoogle Scholar
  7. Boehncke WH, Schon MP (2015) Psoriasis. Lancet 386:983–994PubMedCrossRefPubMedCentralGoogle Scholar
  8. Bolotin D, Petronic-Rosic V (2011a) Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation. J Am Acad Dermatol 64:1017–1024PubMedCrossRefPubMedCentralGoogle Scholar
  9. Bolotin D, Petronic-Rosic V (2011b) Dermatitis herpetiformis. Part II. Diagnosis, management, and prognosis. J Am Acad Dermatol 64:1027–1033PubMedCrossRefPubMedCentralGoogle Scholar
  10. Bramanti TE, Dekker NP, Lozada-Nur F, Sauk JJ, Regezi JA (1995) Heat shock (stress) proteins and gamma delta T lymphocytes in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 80:698–704PubMedCrossRefPubMedCentralGoogle Scholar
  11. Chaiyarit P, Kafrawy AH, Miles DA, Zunt SL, Van Dis ML, Gregory RL (1999) Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis. J Oral Pathol Med 28:210–215PubMedCrossRefPubMedCentralGoogle Scholar
  12. Cho SB, Zheng Z, Ahn KJ, Choi MJ, Cho S, Kim DY, Lee HS, Bang D (2013) Serum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behcet disease. Br J Dermatol 168:977–983PubMedCrossRefPubMedCentralGoogle Scholar
  13. Danieli MG, Candela M, Ricciatti AM, Reginelli R, Danieli G, Cohen IR, Gabrielli A (1992) Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma). J Autoimmun 5:443–452PubMedCrossRefPubMedCentralGoogle Scholar
  14. Das S, Reynolds RV (2014) Recent advances in acne pathogenesis: implications for therapy. Am J Clin Dermatol 15:479–488PubMedCrossRefPubMedCentralGoogle Scholar
  15. Denton CP, Khanna D (2017) Systemic sclerosis. Lancet 390:1685–1699PubMedCrossRefPubMedCentralGoogle Scholar
  16. Di Felice V, Ardizzone N, Marciano V, Bartolotta T, Cappello F, Farina F, Zummo G (2005) Senescence-associated HSP60 expression in normal human skin fibroblasts. Anat Rec A Discov Mol Cell Evol Biol 284:446–453PubMedCrossRefPubMedCentralGoogle Scholar
  17. Eichenfield LF, Krakowski AC, Piggott C, Del Rosso J, Baldwin H, Friedlander SF, Levy M, Lucky A, Mancini AJ, Orlow SJ et al (2013) Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics 131(Suppl 3):S163–S186PubMedCrossRefPubMedCentralGoogle Scholar
  18. Elst EF, Klein M, de Jager W, Kamphuis S, Wedderburn LR, van der ZR, Albani S, Kuis W, Prakken BJ (2008) Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis. Arthritis Rheum 58:547–555PubMedCrossRefPubMedCentralGoogle Scholar
  19. Ergun T, Ince U, Eksioglu-Demiralp E, Direskeneli H, Gurbuz O, Gurses L, Aker F, Akoglu T (2001) HSP 60 expression in mucocutaneous lesions of Behcet’s disease. J Am Acad Dermatol 45:904–909PubMedCrossRefPubMedCentralGoogle Scholar
  20. Farhi D, Dupin N (2010) Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol 28:100–108PubMedCrossRefPubMedCentralGoogle Scholar
  21. Fernandez-Gonzalez F, Vazquez-Alvarez R, Reboiras-Lopez D, Gandara-Vila P, Garcia-Garcia A, Gandara-Rey JM (2011) Histopathological findings in oral lichen planus and their correlation with the clinical manifestations. Med Oral Patol Oral Cir Bucal 16:e641–e646PubMedCrossRefPubMedCentralGoogle Scholar
  22. Flohr C, Mann J (2014) New insights into the epidemiology of childhood atopic dermatitis. Allergy 69:3–16PubMedCrossRefPubMedCentralGoogle Scholar
  23. Gaspari AA (2006) Innate and adaptive immunity and the pathophysiology of psoriasis. J Am Acad Dermatol 54:S67–S80PubMedCrossRefPubMedCentralGoogle Scholar
  24. Gaston JS, Life PF, Bailey LC, Bacon PA (1989) In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients. J Immunol 143:2494–2500PubMedPubMedCentralGoogle Scholar
  25. Gaston JS, Life PF, Jenner PJ, Colston MJ, Bacon PA (1990) Recognition of a mycobacteria-specific epitope in the 65-kD heat-shock protein by synovial fluid-derived T cell clones. J Exp Med 171:831–841PubMedCrossRefPubMedCentralGoogle Scholar
  26. Ghoreishi M, Yokozeki H, Hua WM, Nishioka K (2000) Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis. J Dermatol 27:370–379PubMedCrossRefPubMedCentralGoogle Scholar
  27. Greco A, De Virgilio A, Ralli M, Ciofalo A, Mancini P, Attanasio G, De Vincentiis M, Lambiase A (2018) Behcet's disease: new insights into pathophysiology, clinical features and treatment options. Autoimmun Rev 17:567–575PubMedCrossRefPubMedCentralGoogle Scholar
  28. Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. Lancet 370:263–271PubMedCrossRefPubMedCentralGoogle Scholar
  29. Guilpain P, Mouthon L (2008) Antiendothelial cells autoantibodies in vasculitis-associated systemic diseases. Clin Rev Allergy Immunol 35:59–65PubMedCrossRefPubMedCentralGoogle Scholar
  30. Harper JC (2004) An update on the pathogenesis and management of acne vulgaris. J Am Acad Dermatol 51:S36–S38PubMedCrossRefPubMedCentralGoogle Scholar
  31. Hayashi M, Fujihara K, Beder LB, Yamamoto Y, Hotomi M, Yamanaka N (2009) Pathogenic role of tonsillar lymphocytes in associated with HSP60/65 in Pustulosis palmaris et plantaris. Auris Nasus Larynx 36:578–585PubMedCrossRefPubMedCentralGoogle Scholar
  32. Hohlfeld R, Engel AG (1992) Expression of 65-kd heat shock proteins in the inflammatory myopathies. Ann Neurol 32:821–823PubMedCrossRefPubMedCentralGoogle Scholar
  33. Imamura Y, Kurokawa MS, Yoshikawa H, Nara K, Takada E, Masuda C, Tsukikawa S, Ozaki S, Matsuda T, Suzuki N (2005) Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet’s disease. Clin Exp Immunol 139:371–378PubMedPubMedCentralCrossRefGoogle Scholar
  34. Ismail SB, Kumar SK, Zain RB (2007) Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci 49:89–106PubMedCrossRefPubMedCentralGoogle Scholar
  35. Jamin C, Dugue C, Alard JE, Jousse S, Saraux A, Guillevin L, Piette JC, Youinou P (2005) Induction of endothelial cell apoptosis by the binding of anti-endothelial cell antibodies to Hsp60 in vasculitis-associated systemic autoimmune diseases. Arthritis Rheum 52:4028–4038CrossRefGoogle Scholar
  36. Jassies-van der Lee A, Rutten V, van Kooten P, van der Zee R, Willemse T (2008) Intradermal injection of Hsp60 induces cytokine responses in canine atopic and healthy skin. Cell Stress Chaperones 13:387–391PubMedPubMedCentralCrossRefGoogle Scholar
  37. Kallenberg CG (2014) The diagnosis and classification of microscopic polyangiitis. J Autoimmun 48-49:90–93PubMedCrossRefPubMedCentralGoogle Scholar
  38. Kaneko S, Suzuki N, Yamashita N, Nagafuchi H, Nakajima T, Wakisaka S, Yamamoto S, Sakane T (1997) Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet’s disease (BD) in Japan. Clin Exp Immunol 108:204–212PubMedPubMedCentralCrossRefGoogle Scholar
  39. Kaneko F, Togashi A, Saito S, Sakuma H, Oyama N, Nakamura K, Yokota K, Oguma K (2011) Behcet’s disease (Adamantiades-Behcet’s disease). Clin Dev Immunol 2011:681956CrossRefGoogle Scholar
  40. Kapitein B, Aalberse JA, Klein MR, de Jager W, Hoekstra MO, Knol EF, Prakken BJ (2013) Recognition of self-heat shock protein 60 by T cells from patients with atopic dermatitis. Cell Stress Chaperones 18:87–95PubMedCrossRefPubMedCentralGoogle Scholar
  41. Kasperkiewicz M, Tukaj S, Gembicki AJ, Sillo P, Gorog A, Zillikens D, Karpati S (2014) Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis. Cell Stress Chaperones 19:837–843PubMedPubMedCentralCrossRefGoogle Scholar
  42. Kim J, Krueger JG (2015) The immunopathogenesis of psoriasis. Dermatol Clin 33:13–23PubMedCrossRefPubMedCentralGoogle Scholar
  43. Komiya I, Arimura Y, Nakabayashi K, Yamada A, Osaki T, Yamaguchi H, Kamiya S (2011) Increased concentrations of antibody against heat shock protein in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody positive microscopic polyangiitis. Microbiol Immunol 55:531–538PubMedCrossRefPubMedCentralGoogle Scholar
  44. Kurago ZB (2016) Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol 122:72–80PubMedCrossRefPubMedCentralGoogle Scholar
  45. Lule S, Colpak AI, Balci-Peynircioglu B, Gursoy-Ozdemir Y, Peker S, Kalyoncu U, Can A, Tekin N, Demiralp D, Dalkara T (2017) Behcet disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger. J Autoimmun 84:87–96PubMedCrossRefPubMedCentralGoogle Scholar
  46. Mallon E, Bunker CB (2000) HIV-associated psoriasis. AIDS Patient Care STDs 14:239–246PubMedCrossRefPubMedCentralGoogle Scholar
  47. Marcatili A, Cipollaro dl, Galdiero M, Folgore A, Petrillo G (1997) TNF-alpha, IL-1 alpha, IL-6 and ICAM-1 expression in human keratinocytes stimulated in vitro with Escherichia coli heat-shock proteins. Microbiology 143(Pt 1):45–53PubMedCrossRefPubMedCentralGoogle Scholar
  48. Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, Jimenez HC, Riebeling-Navarro C, Nava ZA, Vera RM, Espinosa G, Jara QJ, Cervera R (2010) Etiopathogenesis of Behcet’s disease. Autoimmun Rev 9:241–245PubMedCrossRefPubMedCentralGoogle Scholar
  49. Menter A, Gottlieb A, Feldman SR, Van Voorhees AS, Leonardi CL, Gordon KB, Lebwohl M, Koo JY, Elmets CA, Korman NJ et al (2008) Guidelines of care for the management of psoriasis and psoriatic arthritis: section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol 58:826–850PubMedCrossRefPubMedCentralGoogle Scholar
  50. Nicolas ME, Krause PK, Gibson LE, Murray JA (2003) Dermatitis herpetiformis. Int J Dermatol 42:588–600PubMedCrossRefPubMedCentralGoogle Scholar
  51. Ohashi K, Burkart V, Flohe S, Kolb H (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164:558–561CrossRefGoogle Scholar
  52. Olson MA, Rogers RS III, Bruce AJ (2016) Oral lichen planus. Clin Dermatol 34:495–504PubMedCrossRefPubMedCentralGoogle Scholar
  53. Pineton dC, Wechsler B, Geri G, Cacoub P, Saadoun D (2012) New insights into the pathogenesis of Behcet’s disease. Autoimmun Rev 11:687–698CrossRefGoogle Scholar
  54. Puig L, Fernandez-Figueras MT, Ferrandiz C, Ribera M, de Moragas JM (1995) Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis. J Am Acad Dermatol 33:985–989PubMedCrossRefPubMedCentralGoogle Scholar
  55. Quartier P, Gherardi RK (2013) Juvenile dermatomyositis. Handb Clin Neurol 113:1457–1463PubMedCrossRefPubMedCentralGoogle Scholar
  56. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A (2010) Pathogenesis of oral lichen planus--a review. J Oral Pathol Med 39:729–734PubMedCrossRefPubMedCentralGoogle Scholar
  57. Seung NR, Park EJ, Kim CW, Kim KH, Kim KJ, Cho HJ, Park HR (2007) Comparison of expression of heat-shock protein 60, toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis. J Cutan Pathol 34:903–911PubMedCrossRefPubMedCentralGoogle Scholar
  58. Shaker O, Ay El-Deen MA, El Hadidi H, Grace BD, El Sherif H, Abdel HA (2007) The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behcet disease. Br J Dermatol 156:32–37CrossRefGoogle Scholar
  59. Shengyuan L, Songpo Y, Wen W, Wenjing T, Haitao Z, Binyou W (2009) Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol 145:1040–1047PubMedCrossRefPubMedCentralGoogle Scholar
  60. Shimizu J, Izumi T, Suzuki N (2012) Aberrant activation of heat shock protein 60/65 reactive T cells in patients with Behcet’s disease. Autoimmune Dis 2012:105205PubMedPubMedCentralGoogle Scholar
  61. Subjeck JR, Sciandra JJ, Johnson RJ (1982) Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol 55:579–584PubMedCrossRefPubMedCentralGoogle Scholar
  62. Thompson C, Piguet V, Choy E (2018) The pathogenesis of dermatomyositis. Br J Dermatol 179:1256–1262Google Scholar
  63. Thyssen JP, Kezic S (2014) Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 134:792–799PubMedCrossRefPubMedCentralGoogle Scholar
  64. Tukaj S, Gorog A, Kleszczynski K, Zillikens D, Karpati S, Kasperkiewicz M (2017) Autoimmunity to heat shock proteins and vitamin D status in patients with celiac disease without associated dermatitis herpetiformis. J Steroid Biochem Mol Biol 173:23–27CrossRefGoogle Scholar
  65. Wang XY, Tao CJ, Wu QY, Yuan CD (2013) Protein extract of ultraviolet-irradiated human skin keratinocytes promote the expression of mitogen-activated protein kinases, nuclear factor-kappaB and interferon regulatory factor-3 in Langerhans cells via toll-like receptor 2 and 4. Photodermatol Photoimmunol Photomed 29:41–48PubMedCrossRefPubMedCentralGoogle Scholar
  66. Weidinger S, Novak N (2016) Atopic dermatitis. Lancet 387:1109–1122CrossRefGoogle Scholar
  67. Wilcox HE, Farrar MD, Cunliffe WJ, Holland KT, Ingham E (2007) Resolution of inflammatory acne vulgaris may involve regulation of CD4+ T-cell responses to Propionibacterium acnes. Br J Dermatol 156:460–465PubMedCrossRefPubMedCentralGoogle Scholar
  68. Wilson N, McArdle A, Guerin D, Tasker H, Wareing P, Foster CS, Jackson MJ, Rhodes LE (2000) Hyperthermia to normal human skin in vivo upregulates heat shock proteins 27, 60, 72i and 90. J Cutan Pathol 27:176–182PubMedCrossRefPubMedCentralGoogle Scholar
  69. Wollenberg A, Oranje A, Deleuran M, Simon D, Szalai Z, Kunz B, Svensson A, Barbarot S, von Kobyletzki L, Taieb A et al (2016) ETFAD/EADV eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. J Eur Acad Dermatol Venereol 30:729–747PubMedCrossRefPubMedCentralGoogle Scholar
  70. Yavuz S, Elbir Y, Tulunay A, Eksioglu-Demiralp E, Direskeneli H (2008) Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. Rheumatol Int 28:401–406PubMedCrossRefPubMedCentralGoogle Scholar
  71. Yazawa N, Fujimoto M, Tamaki K (2007) Recent advances on pathogenesis and therapies in systemic sclerosis. Clin Rev Allergy Immunol 33:107–112PubMedCrossRefPubMedCentralGoogle Scholar
  72. Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O (2003) T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors. FASEB J 17:1567–1569CrossRefGoogle Scholar
  73. Zanoni G, Navone R, Lunardi C, Tridente G, Bason C, Sivori S, Beri R, Dolcino M, Valletta E, Corrocher R et al (2006) In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS Med 3:e358PubMedPubMedCentralCrossRefGoogle Scholar
  74. Zhang L, Pelech SL, Mayrand D, Grenier D, Heino J, Uitto VJ (2001) Bacterial heat shock protein-60 increases epithelial cell proliferation through the ERK1/2 MAP kinases. Exp Cell Res 266:11–20PubMedCrossRefPubMedCentralGoogle Scholar
  75. Zhang L, Pelech S, Uitto VJ (2004) Long-term effect of heat shock protein 60 from Actinobacillus actinomycetemcomitans on epithelial cell viability and mitogen-activated protein kinases. Infect Immun 72:38–45PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Papapit Tuchinda
    • 1
  • Visith Thongboonkerd
    • 2
  1. 1.Department of Dermatology, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand
  2. 2.Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

Personalised recommendations