Hsp60 in Modifications of Nervous System Homeostasis and Neurodegeneration

Caruso Bavisotto, Celeste; Scalia, Federica; Pitruzzella, Alessandro; Górska-Ponikowska, Magdalena; Marino, Claudia; Taglialatela, Giulio

doi:10.1007/978-3-030-23154-5_16

Celeste Caruso Bavisotto^5,6,7,
Federica Scalia^5,6,
Alessandro Pitruzzella^5,6,
Magdalena Górska-Ponikowska^8,9,
Claudia Marino¹⁰ &
…
Giulio Taglialatela¹⁰

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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2 Citations

Abstract

Hsp60 is a critical chaperonin for its role in preserving cell survival and protecting mitochondria against stress conditions. Indeed, mutations or malfunctions of Hsp60 are involved in several human diseases, either genetic or acquired, some of them affecting also the brain. In this chapter, we present several experimental observations supporting the role of Hsp60 in some neurodegenerative diseases. Further, Hsp60, as multifunctional protein, contributes to the protein folding system, to protect mitochondria and is involved in several other cellular pathways that are known to be affected in these diseases. Furthermore, due to its role outside of the mitochondria and in the extracellular fluids, it has also been suggested that Hsp60 has a role in triggering neuroinflammation. Taken together, these considerations strongly suggest the important role for Hsp60 in neurodegenerative diseases and might propose Hp60 as an attractive target for developing future therapies.

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Abbreviations

ACADS:: Acyl-CoA dehydrogenase gene
AD:: Alzheimer’s disease
APP:: Amyloid precursor protein
ATPase:: Adenosine triphosphatase
Aβ:: Amyloid-β peptide
BBB:: Blood brain barrier
CNS:: Central nervous system
CS:: Chaperone system
HD:: Huntington’s disease
Hsp60:: Heat shock protein 60 kDa
HSPD1 :: Heat shock protein family D
HTT:: Huntingtin gene
NDDs:: Neurodegenerative disorders
NFTs:: Neurofibrillary tangles
PD:: Parkinson’s disease
sHsp:: Small heat shock proteins
TLR:: Toll-like receptor

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Acknowledgements

A.P., C.C.B. and F.S. were partially supported by UniPA.

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Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, Palermo, Italy
Celeste Caruso Bavisotto, Federica Scalia & Alessandro Pitruzzella
Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy
Celeste Caruso Bavisotto, Federica Scalia & Alessandro Pitruzzella
Institute of Biophysics, National Research Council, Palermo, Italy
Celeste Caruso Bavisotto
Department of Medical Chemistry, Medical University of Gdansk, Gdańsk, Poland
Magdalena Górska-Ponikowska
Institute of Biomaterials and Biomolecular Systems, Department of Biophysics, University of Stuttgart, Stuttgart, Germany
Magdalena Górska-Ponikowska
Mitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
Claudia Marino & Giulio Taglialatela

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Celeste Caruso Bavisotto
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Federica Scalia
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Correspondence to Celeste Caruso Bavisotto .

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Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA
Alexzander A. A. Asea
Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA
Punit Kaur

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Caruso Bavisotto, C., Scalia, F., Pitruzzella, A., Górska-Ponikowska, M., Marino, C., Taglialatela, G. (2019). Hsp60 in Modifications of Nervous System Homeostasis and Neurodegeneration. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_16

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