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Heat Shock Protein 60: An Effective Target Candidate in Neurological Diseases Treatment

  • Babita Sharma
  • Madhu Smita
  • Ishu Khangwal
  • Rajat Maheshwari
  • Arun Kumar Dangi
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 18)

Abstract

The accumulation of intra- and extracellular misfolded proteins is found to play an imperative role in the progression of several neurological disorders including epilepsy, Alzheimer’s disease, brain tumors, etc. which ultimately causes death worldwide. Heat shock protein (Hsp60) was found to be an important biomolecule that plays an essential role in the removal or degradation of these misfolded proteins and also act as a biomarker in disease prognosis. In neurological diseases, these systems are compromised due to deregulation or mutation of Hsp60 resulting in a large amount of aggregated proteins accumulation. Therefore, the development of novel and more efficient Hsp60 modulators is essential that can modulate the Hsp60 and involved pathways for the treatment of neurological diseases. For this propose, several In silico computational tools are developed, and many tools are under development. In this chapter, we discuss the role of Hsp60 in some more prominent neurological diseases and modulators developed in this direction. Further, we also highlight advanced computational tools that could be used for designing more Hsp60 modulators.

Keywords

Alzheimer disease Brain tumor Epilepsy Heat shock protein 60 Hsp60 modulators neurological disorders 

Abbreviations

AD

Alzheimer’s disease

FLD

Frontotemporal lobar degeneration

Hsp

Heat shock protein

INDD

Integrated neurodegenerative disease database

PDT

Photodynamic therapy

SRSs

Spontaneous recurrent seizures

TLE

Temporal lobe epilepsy

Notes

Acknowledgements

The author acknowledges Maharshi Dayanand University, Rohtak for providing infrastructure and lab facility for the compilation of this interesting and informative book chapter.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Babita Sharma
    • 1
  • Madhu Smita
    • 2
  • Ishu Khangwal
    • 1
  • Rajat Maheshwari
    • 3
  • Arun Kumar Dangi
    • 1
  1. 1.Enzyme Technology and Protein Bioinformatics Laboratory, Department of MicrobiologyMaharshi Dayanand UniversityRohtakIndia
  2. 2.Rahul Chaudhry and PartnersGurugramIndia
  3. 3.Department of MicrobiologyMaharshi Dayanand UniversityRohtakIndia

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