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Home Blood Pressure Monitoring in Clinical Research

  • Angeliki Ntineri
  • Kazuomi Kario
  • Ji-Guang Wang
  • William White
  • George S. StergiouEmail author
Chapter
Part of the Updates in Hypertension and Cardiovascular Protection book series (UHCP)

Abstract

Home blood pressure monitoring (HBPM) performed by patients is a valuable tool in the design and execution of clinical trials in hypertension. In comparison with office blood pressure measurements, HBPM provides a much larger sample of measurements within days, weeks, or months, which are obtained in the usual environment of each individual and prevent several misrepresentative phenomena, such as white-coat and masked hypertension, the placebo effect and observer error and bias. These beneficial features lead to a more accurate definition of hypertension phenotypes and to more homogenous groups selected for clinical research. In addition, HBPM may yield higher reproducibility and improved sensitivity and precision in clinical trials that are designed to investigate circadian blood pressure characteristics, such as nocturnal hypertension, blood pressure variability, as well as long-term treatment-induced changes in blood pressure and in indexes of target organ damage and cardiovascular risk.

Keywords

Home blood pressure Self-measurement Clinical trial design Research Accuracy Study power Methodology Reproducibility Drug effects 

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Copyright information

© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG, part of Springer Nature 2020

Authors and Affiliations

  • Angeliki Ntineri
    • 1
  • Kazuomi Kario
    • 2
  • Ji-Guang Wang
    • 3
  • William White
    • 4
  • George S. Stergiou
    • 1
    Email author
  1. 1.Hypertension Center STRIDE-7National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria HospitalAthensGreece
  2. 2.Division of Cardiovascular Medicine, Department of MedicineJichi Medical University School of Medicine (JMU)TochigiJapan
  3. 3.The Shanghai Institute of HypertensionRuijin Hospital, Shanghai Jiaotong University School of MedicineShanghaiChina
  4. 4.Calhoun Cardiology CenterUniversity of Connecticut School of MedicineFarmingtonUSA

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