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Intense Pulsed Light for Acne Vulgaris

  • Ajay Deshpande
Chapter

Abstract

Acne vulgaris is a self-limiting chronic inflammatory disorder of the pilo-sebaceous unit characterized by exacerbations and remissions. It is often the early manifestation of puberty and, in girls, it appears relatively early. Acne treatment is divided into two parts, topical and systemic. For grades 1 and 2 acne, topical treatment is all that is required but, for grades 3 and 4, systemic drugs, such as tetracyclines, retinoids, etc., are required to control the acne. Chemical peeling with glycolic and salicylic acid, cryosurgery with liquid nitrogen or carbon dioxide, and narrow band ultraviolet light are a few of the supportive procedural treatments for grades 3 and 4 acne. Intense Pulsed Light therapy is an effective and safe modality of treatment in inflammatory grades 3 and 4 acne vulgaris.

Keywords

Acne vulgaris Intense pulsed light 

References

  1. 1.
    Williams C, Layton AM. Persistent acne in women: Implications for the patient and for therapy. Am J Clin Dermatol. 2006;7:281–90.CrossRefGoogle Scholar
  2. 2.
    Lucky AW, Biro FM, Huster GA, Leach AD, Morrison JA, Ratterman J. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol. 1994;130:308–14.CrossRefGoogle Scholar
  3. 3.
    Vulgaris A, Eruptions A. Fitzpatrick’s dermatology in general medicine. 7th ed. New York: McGraw-Hill; 2012. p. 690–703.Google Scholar
  4. 4.
    Gupta MA, Gupta AK. Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol. 1998;139:846–50.CrossRefGoogle Scholar
  5. 5.
    Mallon E, Newton JN, Klassen A, Stewart-Brown SL, Ryan TJ, Finlay AY. The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol. 1999;140:672–6.CrossRefGoogle Scholar
  6. 6.
    Haider A, Shaw JC. Treatment of acne vulgaris. JAMA. 2004;292:726–35.CrossRefGoogle Scholar
  7. 7.
    Leyden JJ. Therapy for acne vulgaris. N Engl J Med. 1997;336:1156–62.CrossRefGoogle Scholar
  8. 8.
    Skidmore R, Kovach R, Walker C, Thomas J, Bradshaw M, Leyden J, Powala C, Ashley R. Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Arch Dermatol. 2003;139:459–64.CrossRefGoogle Scholar
  9. 9.
    Ortonne JP. Oral isotretinoin treatment policy. Do we all agree? Dermatology. 1997;195(Suppl 1):34–40.CrossRefGoogle Scholar
  10. 10.
    Weiss JS. Current options for the topical treatment of acne vulgaris. Pediatr Dermatol. 1997;14:480–8.CrossRefGoogle Scholar
  11. 11.
    Bojar RA, Cunliffe WJ, Holland KT. The short-term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora. Br J Dermatol. 1995;132:204–8.CrossRefGoogle Scholar
  12. 12.
    Gollnick H, Schramm M. Topical therapy in acne. J Eur Acad Dermatol Venereol. 1998;11(Suppl 1):S8–12; discussion S28-9CrossRefGoogle Scholar
  13. 13.
    Ross JI, Snelling AM, Carnegie E, Coates P, Cunliffe WJ, Bettoli V, et al. Antibiotic-resistant acne: lessons from Europe. Br J Dermatol. 2003;148:467–78.CrossRefGoogle Scholar
  14. 14.
    Sinnott SJ, Bhate K, Margolis DJ, Langan SM. Antibiotics and acne: an emerging iceberg of antibiotic resistance. Br J Dermatol. 2016;175:1127–8.  https://doi.org/10.1111/bjd.15129.CrossRefPubMedGoogle Scholar
  15. 15.
    Rai R, Natrajan K. Laser and light based treatments of acne. Indian J Dermatol Venereol Leprol. 2013;79:300–9.  https://doi.org/10.4103/0378-6323.110755.CrossRefPubMedGoogle Scholar
  16. 16.
    Babilas P. Light-assisted therapy in dermatology - the use of IPL. Med Laser Appl. 2010;25:61–9.CrossRefGoogle Scholar
  17. 17.
    Elman M, Lebzelter J. Light therapy in the treatment of acne vulgaris. Dermatol Surg. 2004;30(2 Pt 1):139–46.PubMedGoogle Scholar
  18. 18.
    Barakat MT, Maftah NH, Khayyat EI, Abdelhakim ZA. Significant reduction of inflammation and sebaceous gland size in acne vulgaris lesions after intense pulsed light treatment. Dermatol Ther. 2017;30:e12418.  https://doi.org/10.1111/dth.12418.CrossRefGoogle Scholar
  19. 19.
    Taylor M, Porter R, Gonzalez M. Intense pulsed light may improve inflammatory acne through TNF-alpha down regulation. J Cosmet Laser Therapy. 2014;16:96–103.  https://doi.org/10.3109/14764172.2013.864198.CrossRefGoogle Scholar
  20. 20.
    Ali MM, Porter RM, Gonzalez M. Intense pulsed light enhances transforming growth factor beta 1/smad3 signaling in acne-prone skin. J Cosmet Dermatol. 2013;12:195–203.CrossRefGoogle Scholar
  21. 21.
    Cureda-Galindo E, Díaz-Gil G, Palomar-Gallego MA, Linares-GarcíaValdecasas R. Intense pulsed light therapy induces synthesis of dermal extracellular proteins in vitro. Lasers Med Sci. 2015;30:1931–9.  https://doi.org/10.1007/s10103-015-1787-5.CrossRefGoogle Scholar
  22. 22.
    Cao Y, Huo R, Feng Y, Li Q, Wang F. Effects of intense pulsed light on the biological properties and ultrastructure of skin dermal fibroblasts: potential role in photoaging. Photomed Laser Surg. 2011;29:327–32.  https://doi.org/10.1089/pho.2010.2867.CrossRefPubMedGoogle Scholar
  23. 23.
    Ashkenazi H, Malik Z, Harth Y, Nitzan Y. Eradication of Propionibacterium acnes by its endogenous porphyrins after illumination with high intensity blue light. FEMS Immunol Med Microbiol. 2003;35:17–24.CrossRefGoogle Scholar
  24. 24.
    Liu J, Liu J, Ren Y, Li B, Lu S. Comparative efficacy of intense pulsed light for different erythema associated with rosacea. J Cosmet Laser Ther. 2014;16:324–7.  https://doi.org/10.3109/14764172.2014.957218.CrossRefPubMedGoogle Scholar
  25. 25.
    Deshpande AJ. Efficacy and safety evaluation of high-density Intense Pulsed Light in the treatment of Grades II and IV acne vulgaris as monotherapy in dark-skinned women of child bearing age. J Clin Aesthet Dermatol. 2018;11:43–8.PubMedPubMedCentralGoogle Scholar
  26. 26.
    Kumaresan M, Srinivas CR. Efficacy of IPL in treatment of acne vulgaris: Comparison of single-and burst pulse mode in IPL. Indian J Dermatol. 2011;55:370–2.  https://doi.org/10.4103/0019-5154.74550.CrossRefGoogle Scholar
  27. 27.
    Mei X, Shi W, Piao Y. Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. Photodermatol Photoimmunol Photomed. 2013;29:90–6.  https://doi.org/10.1111/phpp.12031.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Ajay Deshpande
    • 1
  1. 1.Maharashtra Medical Foundation, Joshi HospitalPuneIndia

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