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Alkylating Agents

  • Debra A. Goldstein
  • Kara C. LaMattina
Chapter

Abstract

The alkylating agents cyclophosphamide and chlorambucil have been utilized in medicine for over 50 years. As our knowledge about the pharmacokinetics of these agents has grown, treatment regimens have evolved. While alkylating agents have been shown to be highly effective in the treatment of ocular inflammation, their use has been limited by the risks of serious side effects including sterility and malignancy. They remain an important tool in the arsenal of treatments, however, particularly in the case of sight-threatening disease.

Keywords

Alkylating agents Chlorambucil Cyclophosphamide Behçet disease Scleritis Sympathetic ophthalmia Serpiginous choroiditis Malignancy Sterility Premature ovarian failure 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Debra A. Goldstein
    • 1
  • Kara C. LaMattina
    • 2
  1. 1.Department of OphthalmologyNorthwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Department of OphthalmologyBoston University School of MedicineBostonUSA

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