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Analysis of Three-Chamber View Tagged Cine MRI in Patients with Suspected Hypertrophic Cardiomyopathy

  • Mikael Kanski
  • Teodora Chitiboi
  • Lennart Tautz
  • Anja Hennemuth
  • Dan Halpern
  • Mark V. Sherrid
  • Leon AxelEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11504)

Abstract

Cardiovascular magnetic resonance imaging (CMR) is frequently used for patients with suspected hypertrophic cardiomyopathy (HCM). However, although magnetization-tagged MRI can provide quantitative assessment of regional function in HCM, it is not routinely used in clinical CMR of HCM. Therefore, we investigated the added value of acquiring a single three-chamber (3Ch) tagged cine image sequence to our clinical HCM protocol. Forty-eight patients with HCM, five patients with “septal knuckle” (SK), and 20 healthy volunteers underwent CMR at 1.5T, including a 3Ch tagged cine sequence. The images were analyzed for regional deformation (strain) and myocardial wall thickness, and results were compared to data from healthy volunteers. In HCM, we found a reduced tangential strain (p < 0.003) with decreased relaxation in hypertrophied segments, and mildly reduced strain (p < 0.035) with decreased relaxation in segments without hypertrophy. There was an inverse correlation between principal strain magnitude and local septal wall thickness (p < 0.001). Patients with SK had a higher tangential strain in the basal septum compared to patients with asymmetrical septal hypertrophy due to HCM, which may aid in differentiating focal HCM from SK. Thus, adding a 3Ch tagged MRI sequence to clinical CMR examinations of suspected HCM patients can provide functional information, aiding in differentiating SK from HCM, with minimal additional time cost.

Keywords

MRI tagging Hypertrophic cardiomyopathy Strain 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mikael Kanski
    • 1
  • Teodora Chitiboi
    • 1
    • 2
  • Lennart Tautz
    • 3
    • 4
  • Anja Hennemuth
    • 3
    • 4
  • Dan Halpern
    • 5
  • Mark V. Sherrid
    • 6
  • Leon Axel
    • 1
    Email author
  1. 1.Department of Radiology, NYU Langone HealthNYU School of MedicineNew YorkUSA
  2. 2.Siemens HealthineersPrincetonUSA
  3. 3.Charité University HospitalBerlinGermany
  4. 4.Fraunhofer Institute for Medical Image Computing - MEVISBremenGermany
  5. 5.Division of Cardiology, NYU Langone HealthNYU School of MedicineNew YorkUSA
  6. 6.Hypertrophic Cardiomyopathy Program, Division of Cardiology, NYU Langone HealthNYU School of MedicineNew YorkUSA

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