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Comparing Subjects with Reference Populations - A Visualization Toolkit for the Analysis of Aortic Anatomy and Pressure Distribution

  • Sahar KarimkeshtehEmail author
  • Lilli Kaufhold
  • Sarah Nordmeyer
  • Lina Jarmatz
  • Andreas Harloff
  • Anja Hennemuth
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11504)

Abstract

The analysis of anatomical and hemodynamic vessel parameters plays an important role in diagnosis and therapy planning for aortic diseases. Normal values and decision thresholds are usually based on global or local parameters provided by population studies. In order to enable a more holistic comparison of a single subject and a matching reference population we have developed a spatiotemporal normalization concept for the analysis of 4D PC MRI data of the thoracic aorta. This enables the comparison of geometric properties and pressure differences along the vessel course as well as in a sector model, which represents a cross-sectional value distribution. We tested the applicability of the presented approach by comparing subjects with aortic diseases to matching subgroups of a normal reference population. The presented framework enabled a visual and quantitative assessment of the local geometric and pressure distribution changes of different pathological alterations of the aorta. It will be extended to integrate further hemodynamic properties and larger reference cohorts to support clinical decision making based on hemodynamic information in near future.

Keywords

4D PC MRI Aortic disease Pressure distribution Population study 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sahar Karimkeshteh
    • 1
    • 2
    Email author
  • Lilli Kaufhold
    • 1
    • 2
  • Sarah Nordmeyer
    • 3
  • Lina Jarmatz
    • 2
  • Andreas Harloff
    • 4
  • Anja Hennemuth
    • 1
    • 2
  1. 1.Fraunhofer MEVISBremenGermany
  2. 2.Charité – Universitätsmedizin BerlinBerlinGermany
  3. 3.Deutsches Herzzentrum BerlinBerlinGermany
  4. 4.Universitätsklinikum FreiburgFreiburgGermany

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