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Cannabinoids and Cardiovascular System

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Recent Advances in Cannabinoid Physiology and Pathology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1162))

Abstract

Cannabinoids influence cardiovascular variables in health and disease via multiple mechanisms. The chapter covers the impact of cannabinoids on cardiovascular function in physiology and pathology and presents a critical analysis of the proposed signalling pathways governing regulation of cardiovascular function by endogenously produced and exogenous cannabinoids. We know that endocannabinoid system is overactivated under pathological conditions and plays both a protective compensatory role, such as in some forms of hypertension, atherosclerosis and other inflammatory conditions, and a pathophysiological role, such as in disease states associated with excessive hypotension. This chapter focuses on the mechanisms affecting hemodynamics and vasomotor effects of cannabinoids in health and disease states, highlighting mismatches between some studies. The chapter will first review the effects of marijuana smoking on cardiovascular system and then describe the impact of exogenous cannabinoids on cardiovascular parameters in humans and experimental animals. This will be followed by analysis of the impact of cannabinoids on reactivity of isolated vessels. The article critically reviews current knowledge on cannabinoid induction of vascular relaxation by cannabinoid receptor-dependent and –independent mechanisms and dysregulation of vascular endocannabinoid signaling in disease states.

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Abbreviations

2-AG:

2-Arachidonoylglycerol

ACPA:

arachidonylcyclopropylamide

BKCa :

large conductance calcium-activated potassium channel, KCa1.1

CB1:

cannabinoid receptor type 1

CB2:

cannabinoid receptor type 2

CBe:

endothelial cannabinoid receptor

CGRP:

calcitonin gene-related peptide

COX:

cyclooxygenase, prostaglandin-endoperoxide synthase

DOC salt hypertension:

deoxycorticosterone acetate-induced hypertension

EDHF:

endothelium-derived hyperpolarizing factor

FAAH:

fatty acid amide hydrolase

IKCa :

intermediate conductance calcium-activated potassium channel, KCa3.1

KATP:

ATP-sensitive potassium channel

NAGly:

N-arachidonoyl glycine

NCX:

Na+-Ca2+ exchanger

NO:

nitric oxide

PPAR:

peroxisome proliferator-activated receptor

SHR:

spontaneously hypertensive rats

TASK:

TWIK-related acid-sensitive potassium channel

THC:

Δ9-tetrahydrocannabinol

TRPA:

transient receptor potential cation channel subfamily A (ankyrin)

TRPV:

transient receptor potential cation channel subfamily V (vanniloid)

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Acknowledgements

The author gratefully acknowledges financial support from the Austrian Science Fund, FWF, grant # P27238-B27.

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  1. Circulatory Physiology Department, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kiev, Ukraine

    Alexander I. Bondarenko

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  1. Alexander I. Bondarenko
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Correspondence to Alexander I. Bondarenko .

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  1. Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA

    Anna N. Bukiya

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Bondarenko, A.I. (2019). Cannabinoids and Cardiovascular System. In: Bukiya, A. (eds) Recent Advances in Cannabinoid Physiology and Pathology. Advances in Experimental Medicine and Biology, vol 1162. Springer, Cham. https://doi.org/10.1007/978-3-030-21737-2_5

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