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Endocannabinoid System Components: Overview and Tissue Distribution

  • Neal Joshi
  • Emmanuel S. OnaiviEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1162)

Abstract

Marijuana/cannabinoid research has been transformed into mainstream science during the last half-century. Evidence based research and remarkable biotechnological advances demonstrate that phytocannabinoids and endocannabinoid (eCBs) acting on cannabinoid receptors (CBRs) regulate various aspects of human physiological, behavioral, immunological and metabolic functions. The distribution and function of the components of the endocannabinoid system (ECS) in the central nervous system (CNS) and immune processes have garnished significant research focus with major milestones. With these advances in biotechnology, rapid extension of the ECS research in the periphery has gained momentum. In this chapter, we review the components and tissue distribution of this previously unknown but ubiquitous and complex ECS that is involved in almost all aspects of mammalian physiology and pathology.

Keywords

Cannabis Cannabinoids Endocannabinoids Cannabinoid receptors 

Abbreviations

2-AG

2-arachidonyl glycerol

CBRs

cannabinoid receptors

CNS

central nervous system

eCB

endocannabinoids

ECS

endocannabinoid system

ENS

enteric nervous system

ER

endoplasmic reticulum

GABA

gamma-aminobutyric acid

GI

gastrointestinal

mtCBR

mitochondrial cannabinoid receptor

NAc

nucleus accumbens

p-CREB

phosphor-cAMP response element-binding protein

PPARs

peroxisome proliferator-activated receptors

THC

tetrahydrocannabinol

TRPV1

transient receptor potential vanilloid type 1

CNR

cannabinoid receptor gene

GPCR

G-protein coupled receptor

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Rowan University School of Osteopathic MedicineStratfordUSA
  2. 2.Department of BiologyWilliam Paterson UniversityWayneUSA

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