Regenerative Treatments: Microneedling and PRP

  • Colombina Vincenzi
  • Benedetta Marisaldi
  • Antonella Tosti


The treatment of hair disorders is an important part of clinical dermatology, given the prevalence of the problem and the great impact on patients’ quality of life. Many new treatments have been investigated in recent years, such as platelet-rich plasma (PRP) and microneedling, which have emerged as promising regenerative therapies.

These techniques were initially used by the medical community in fields other than dermatology; however, they have recently started to be popular among dermatologists for stimulating follicular regeneration. Several studies and case reports have demonstrated the therapeutic effectiveness of PRP and microneedling in hair loss disorders, but more evidence-based studies are needed to establish their real benefits.

Our experience leads us to suggest using these techniques in association with existing hair growth-promoting therapies, or alone when there are contraindications to medical treatments.


Hair growth Regenerative treatments Microneedling Growth factors Platelet-rich plasma Androgenetic alopecia Alopecia areata WNT pathway β-Catenin Cytokines 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Colombina Vincenzi
    • 1
  • Benedetta Marisaldi
    • 1
  • Antonella Tosti
    • 2
  1. 1.Dermatology, Private Hospital NigrisoliBolognaItaly
  2. 2.Fredric Brandt Endowed Professor of Dermatology, Dr. Phillip Frost Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA

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