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Chronic Diarrhea

  • Nasrin Behniafard
  • Majid Aflatoonian
Chapter

Abstract

  • Very-early onset inflammatory bowel disease (VEO-IBD), refers to the onset of IBD under 6 years of age

  • Presence of non-specific colitis, higher frequency of pan-colitis, perianal involvement, and fistula resistant to biologic agents distinguish VEO-IBD differs from other types of pediatric-onset IBD

  • Early onset IBD (EO-IBD), i.e. onset of IBD before 10 years of age, and VEO-IBD account for most of the genetic causes of IBD

  • Early-onset IBD is associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), X-linked lymphoproliferative (XLP) disease and chronic granulomatous disease (CGD)

  • Hematopoietic stem cell transplantation can eliminate signs of intestinal involvement in IBD associated with mutations in either of the IL10, IL10RA, or IL10RB genes

Keywords

Very-early onset inflammatory bowel disease IL10 receptor gene Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome syndrome X-linked lymphoproliferative disease Chronic granulomatous disease 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nasrin Behniafard
    • 1
    • 2
  • Majid Aflatoonian
    • 3
  1. 1.Department of Allergy and Clinical Immunology of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical SciencesYazdIran
  2. 2.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN)TehranIran
  3. 3.Department of Pediatrics Gastroenterology of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical SciencesYazdIran

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