Advertisement

Brothers with Recurrent Sinopulmonary Infections and Chronic Lung Disease

  • Anastasiia Bondarenko
  • Liudmyla Chernyshova
Chapter

Abstract

Late diagnosis in patients with X-linked agammaglobulinemia (XLA) is associated with irreversible pulmonary complications such as bronchiectasis
  • Simple screening methods, such as serum protein fractions may be useful in suspecting of antibody deficiency

  • Medical treatment for XLA is by lifelong immunoglobulin replacement using Intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG)

  • Use of plasma for immunoglobulin substitution is dangerous due to possibility of transmission of blood-borne infections

  • It is necessary to remember the inexpediency of serological tests is suspicion of infections and using only direct methods of detecting the pathogen

Keywords

Chronic lung disease Intravenous immunoglobulin Lymphocyte subsets enumeration 

References

  1. 1.
    de Vries E. Patient-centred screening for primary immunodeficiency: a multi-stage diagnostic protocol designed for non-immunologists. Clin Exp Immunol. 2006;145(2):204–14.CrossRefGoogle Scholar
  2. 2.
    O’Connell TX, Horita TJ, Kasravi B. Understanding and interpreting serum protein electrophoresis. Am Fam Physician. 2005;71(1):105–12.PubMedGoogle Scholar
  3. 3.
    Serum protein electrophoresis. [database on the Internet]. Accessed: Retrieved 2 Oct 2013.Google Scholar
  4. 4.
    Reale M, Iarlori C, Feliciani C, Gambi D. Peripheral chemokine receptors, their ligands, cytokines and Alzheimer’s disease. J Alzheimer’s Dis. 2008;14(2):147–59.CrossRefGoogle Scholar
  5. 5.
    Quinti I, Soresina A, Guerra A, Rondelli R, Spadaro G, Agostini C, Milito C, Trombetta AC, Visentini M, Martini H, Plebani A, Fiorilli M. Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study. J Clin Immunol. 2011;31(3):315–22.CrossRefGoogle Scholar
  6. 6.
    Abolhassani H, Sadaghiani MS, Aghamohammadi A, Ochs HD, Rezaei N. Home-based subcutaneous immunoglobulin versus hospital-based intravenous immunoglobulin in treatment of primary antibody deficiencies: systematic review and meta analysis. J Clin Immunol. 2012;32(6):1180–92.CrossRefGoogle Scholar
  7. 7.
    Bezrodnik L, Gomez Raccio A, Belardinelli G, Regairaz L, Diaz Ballve D, Seminario G, Moreira I, Riganti C, Cantisano C, Diaz H, Di Giovanni D. Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: a multicenter study in Argentina. J Clin Immunol. 2013;33(7):1216–22.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anastasiia Bondarenko
    • 1
  • Liudmyla Chernyshova
    • 1
  1. 1.Shupyk National Medical Academy for Postgraduate Education, Department of Pediatric Infectious Diseases and Pediatric ImmunologyKievUkraine

Personalised recommendations