Probable Sepsis

  • Javad Ghaffari


  • Treatment of the accelerated phase of Chediak-Higashi syndrome consists of etoposide, steroids, and intrathecal methotrexate followed by maintenance cyclosporine A

  • Remission is achieved in 75% of individuals within 8 weeks and once remission occurs, prompt hematopoietic stem cell transplantation is recommended


Accelerated phase Chediak-Higashi syndrome Hematopoietic stem cell transplantation 


  1. 1.
    Filipovich AH. Hemophagocytic lymphohistiocytosis and related disorders. Curr Opin Allergy Clin Immunol. 2006;6(6):410–5.CrossRefGoogle Scholar
  2. 2.
    Eapen M, DeLaat C, Baker K, Cairo M, Cowan M, Kurtzberg J, Steward C, Veys P, Filipovich A. Hematopoietic cell transplantation for Chediak-Higashi syndrome. Bone Marrow Transplant. 2007;39(7):411.CrossRefGoogle Scholar
  3. 3.
    Haddad E, Le Deist F, Blanche S, Benkerrou M, Rohrlich P, Vilmer E, Griscelli C, Fischer A. Treatment of Chediak-Higashi syndrome by allogenic bone marrow transplantation: report of 10 cases. Blood. 1995;85(11):3328–33.PubMedGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Javad Ghaffari
    • 1
  1. 1.Mazandaran University of Medical SciencesSariIran

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