The most common infectious agents in combined immunodeficiencies are intracellular pathogens, such as cytomegalovirus, herpes simplex virus, Pneumocystis jirovecii, Salmonella and Cryptosporidium.
Immunophenotyping in patients with MHC class II deficiency shows absent or very low HLA-DR expression on B lymphocytes, monocytes or activated T lymphocytes, with reduced CD4+ cell counts leading to an inverted CD4+/CD8+ ratio
KeywordsMHC class II deficiency HLA-DR CD4+/CD8+ ratio Pneumocystis jirovecii
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