Intestinal Cryptosporidiosis

  • Reem Walid Mohammed
  • Abduarahman Almutairi
  • Omar K. Alkhairy


Cryptosporidium parvum is a known cause of sclerosing cholangitis in CD40L hyper IgM syndrome. Diagnostic feature of intrahepatic biliary obstruction is highly suggestive of this condition

The combined primary immunodeficiency caused by CD40L mutations is fully corrected by stem cell transplant only

Treatment of Cryptosporidium infection is based on nitazoxanide and parmomycin for acute infection

Azithromycin could be preserved for long-term prophylaxis of Cryptosporidium infection


Cryptosporidium parvum Sclerosing cholangitis Hyper IgM syndrome 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Reem Walid Mohammed
    • 1
    • 2
  • Abduarahman Almutairi
    • 3
  • Omar K. Alkhairy
    • 4
  1. 1.Pediatric immunology and Allergy, Department of PediatricsKing Faisal Specialist Hospital and research centreRiyadhSaudi Arabia
  2. 2.College of Medicine, alfaisal UniversityRiyadhSaudi Arabia
  3. 3.Department of PediatricsKing Abdullah Specialist Children HospitalRiyadhSaudi Arabia
  4. 4.Department of Pathology and Laboratory MedicineMinistry of National Guard - Health AffairsRiyadhSaudi Arabia

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