Non-Malignant Lymphoproliferation

  • Irina Kondratenko
  • Olga Pashchenko
  • Andrey Bologov


Atypical manifestations of activated phosphoinositide 3-kinase δ syndrome type 2 (APDS2) can include warts, mild infections, and selective IgA deficiency

APDS2 must be differentiated from other primary immunodeficiency disroders with lymphoproliferation, infections and hypogammaglobulinemia.

Rapamycin is the most specific, pathology directed treatment for APDS type 2


Rapamycin mTOR Activated PI3K-delta syndrome type 2 Lymphoproliferation 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Irina Kondratenko
    • 1
    • 2
  • Olga Pashchenko
    • 2
  • Andrey Bologov
    • 2
  1. 1.Department of Clinical Immunology and RheumatologyRussian Children’s Clinical Hospital of Pirogov Russian National Research Medical UniversityMoscowRussia
  2. 2.Department of ImmunologyPirogov Russian National Research Medical UniversityMoscowRussia

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