Weakness and Anemia

  • Anastasiia Bondarenko


Common variable immunodeficiency (CVID) is characterized by defective antibody production, recurrent infections, notably of the respiratory tract, autoimmune phenomena and cancer

Prevalence of vitamin B12 deficiency is higher in patients with CVID

Approximately 20% of patients with CVID have severe gastroenteropathy with atrophic gastritis and severe malabsorption. Nodular lymphoid hyperplasia and chronic inflammatory bowel disease are among other complications of CVID that affect the gut

This highlights the need to be aware of and actively screen for potential development of vitamin deficiencies in CVID

Megaloblastic anemia occurs due to impaired DNA synthesis resulting from deficiencies of vitamin B12 (cobalamin) and folate

Signs and symptoms arising out of vitamin B12 deficiency are varied and non-specific

Serum total cobalamin and folate levels are the initial tests of choice in megaloblastic anemia, as they are widely available and cost-effective

Early vitamin B12 replacement is important in preventing potentially irreversible neurologic damage


Common variable immunodeficiency Vitamin B12 Cobalamin Homocysteine, Methyl malonic acid 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anastasiia Bondarenko
    • 1
  1. 1.Shupyk National Medical Academy for Postgraduate Education, Department of Pediatric Infectious Diseases and Pediatric ImmunologyKievUkraine

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