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Allergy and Recalcitrant Wart

  • Marzieh Tavakol
Chapter

Abstract

  • Severe atopic dermatitis, recurrent skin and pulmonary infections that lead to abscess formation and elevated IgE serum level are main manifestations of hyper-IgE syndrome

  • Mutations in DOCK8 and TYK2 genes lead to autosomal recessive hyper-IgE syndrome

  • Dock8 deficiency impairs immigration of dendritic cells to regional lymph nodes, interferes with T, B, and NK cells activity and reduces their life span

Keywords

DOCK8 Atopic dermatitis Hyper-IgE syndrome 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marzieh Tavakol
    • 1
    • 2
    • 3
  1. 1.Non-communicable Diseases Research Center, Alborz University of Medical SciencesKarajIran
  2. 2.Department of Allergy and Clinical ImmunologyShahid Bahonar Hospital, Alborz University of Medical SciencesKarajIran
  3. 3.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN)TehranIran

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