Allergy and Recalcitrant Wart

  • Marzieh Tavakol


  • Severe atopic dermatitis, recurrent skin and pulmonary infections that lead to abscess formation and elevated IgE serum level are main manifestations of hyper-IgE syndrome

  • Mutations in DOCK8 and TYK2 genes lead to autosomal recessive hyper-IgE syndrome

  • Dock8 deficiency impairs immigration of dendritic cells to regional lymph nodes, interferes with T, B, and NK cells activity and reduces their life span


DOCK8 Atopic dermatitis Hyper-IgE syndrome 


  1. 1.
    Ong PY, Leung DY. Bacterial and viral infections in atopic dermatitis: a comprehensive review. Clin Rev Allergy Immunol. 2016;51(3):329–37.CrossRefGoogle Scholar
  2. 2.
    Pichard DC, Freeman AF, Cowen EW. Primary immunodeficiency update: part I. Syndromes associated with eczematous dermatitis. J Am Acad Dermatol. 2015;73(3):355–64.CrossRefGoogle Scholar
  3. 3.
    Yong PF, Freeman AF, Engelhardt KR, Holland S, Puck JM, Grimbacher B. An update on the hyper-IgE syndromes. Arthritis Res Ther. 2012;14(6):228.CrossRefGoogle Scholar
  4. 4.
    Mogensen TH. Primary immunodeficiencies with elevated IgE. Int Rev Immunol. 2016;35(1):39–56.PubMedGoogle Scholar
  5. 5.
    Freeman AF, Olivier KN. Hyper-IgE syndromes and the lung. Clin Chest Med. 2016;37(3):557–67.CrossRefGoogle Scholar
  6. 6.
    Zhang Q, Su HC. Hyperimmunoglobulin E syndromes in pediatrics. Curr Opin Pediatr. 2011;23(6):653–8.CrossRefGoogle Scholar
  7. 7.
    Biggs CM, Keles S, Chatila TA. DOCK8 deficiency: insights into pathophysiology, clinical features and management. Clin Immunol. 2017;181:75–82.CrossRefGoogle Scholar
  8. 8.
    Rezaei N, Hedayat M, Aghamohammadi A, Nichols KE. Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies. J Allergy Clin Immunol. 2011;127(6):1329–41. e2CrossRefGoogle Scholar
  9. 9.
    Freeman AF, Holland SM. Clinical manifestations of hyper IgE syndromes. Dis Markers. 2010;29(3–4):123–30.CrossRefGoogle Scholar
  10. 10.
    Su HC. DOCK8 (Dedicator of cytokinesis 8) deficiency. Curr Opin Allergy Clin Immunol. 2010;10(6):515–20.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marzieh Tavakol
    • 1
    • 2
    • 3
  1. 1.Non-communicable Diseases Research Center, Alborz University of Medical SciencesKarajIran
  2. 2.Department of Allergy and Clinical ImmunologyShahid Bahonar Hospital, Alborz University of Medical SciencesKarajIran
  3. 3.Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN)TehranIran

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