Recurrent Edema

  • Peter JandusEmail author


The most common triggers of angioedema include mechanical trauma, mental stress, and airway infections

Hereditary angioedema (HAE) is caused by deficiency or dysfunction of the SERPING1 gene and is inherited in an autosomal dominant pattern

Three types of HAE have been described: type 1, characterized by low production of functionally active C1 esterase inhibitor (C1-INH), type 2 characterized by normal or elevated levels of C1-INH but with functional impairment of the protein, and type 3 present with similar clinical manifestations, but no abnormalities in C1-INH level or function

Symptoms often worsen during puberty, introduction of estrogen-containing medications for acne or birth control, in females

Plasma-derived C1-INH, like Berinert and Cinryze can be used for the treatment of acute attacks, for short-term or long-term prophylaxis of HEA by taking into account local approvals


Hereditary angioedema C1 esterase inhibitor Berinert 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Immunology and Allergology, Department of Internal MedicineUniversity Hospital and Medical FacultyGenevaSwitzerland

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